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Thromboxane synthase Antibody (PA5-89188) in WB
Western blot analysis of Thromboxane synthase in extracts of various cell lines. Samples were incubated with Thromboxane synthase Polyclonal antibody (Product # PA5-89188) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-89188
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 355-534 of human Thromboxane synthase (NP_0010522)
偶联物
形式
Liquid
浓度
1.15 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2805405
产品详细信息
Immunogen sequence: TYLLATNPDC QEKLLREVDV FKEKHMAPEF CSLEEGLPYL DMVIAETLRM YPPAFRFTRE AAQDCEVLGQ RIPAGAVLEM AVGALHHDPE HWPSPETFNP ERFTAEARQQ HRPFTYLPFG AGPRSCLGVR LGLLEVKLTL LHVLHKFRFQ ACPETQVPLQ LESKSALGPK NGVYIKIVSR; Positive Samples: THP-1, A-549, NCI-H460; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein
靶标信息
Thromboxane synthase encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; Hydroperoxy icosatetraenoate dehydratase; platelet, cytochrome P450, subfamily V; thromboxane A synthase 1 (platelet); Thromboxane-A synthase; TS; TXA synthase
基因别名: BDPLT14; CYP5; CYP5A1; GHOSAL; TBXAS1; THAS; TS; TXAS; TXS
UniProt ID: (Human) P24557, (Mouse) P36423
Entrez Gene ID: (Human) 6916, (Mouse) 21391
monooxygenase activity
thromboxane-A synthase activity
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme binding
12-hydroxyheptadecatrienoic acid synthase activity
oxidoreductase activity
isomerase activity
metal ion binding
isomerase
metabolite interconversion enzyme
icosanoid metabolic process
cyclooxygenase pathway
oxidation-reduction process
prostaglandin biosynthetic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
cellular chloride ion homeostasis
positive regulation of vasoconstriction
