Invitrogen

Toxoplasma gondii SAG1 Monoclonal Antibody (D61S)

产品信息

MA5-18268

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:10-1:50

查看3篇已发表文章 3篇已发表文章

免疫细胞化学 (ICC/IF)

1:10-1:50

- -

酶联免疫吸附实验 (ELISA)

1:20-1:200

产品规格

种属反应

Protozoa

已发表种属

Protozoa

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

D61S

抗原

Toxoplasma gondii native protein

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

100 µg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2

内含物

0.1% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539642

产品详细信息

This antibody recognizes the SAG1 protein of T. gondii.

Purity is >90%.

靶标信息

Toxoplasma is a crescent shaped sporozoan that lives as intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. It is transmitted via raw/undercooked meat, contaminated soil, or by direct contact. Infection due to Toxoplasma gondii usually occurs in pregnant women where a variable degree of immunosuppression may exist or in patients receiving immunosuppressive drug therapy following organ transplant. Toxoplasma infects tissue of the GI tract where an active infection is accompanied by fever and enlargement of the spleen. Symptoms of toxoplasmosis are generally mild but severe infection of lymph nodes may occur. Congenital toxoplasmosis, in which the maternal infection is transmitted during pregnancy, can produce blindness or mental retardation in the newborn. Toxoplasma gondii infections in humans are widespread but vary greatly by region. The organism enters the intestinal epithelium and can spread to other host tissues. In healthy individuals the infection is usually asymptomatic. However, for individuals with compromised immune systems, a Toxoplasma infection can cause serious health problems.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

CRISPR-based oligo recombineering prioritizes apicomplexan cysteines for drug discovery.

Nature microbiology

Benns HJ,Storch M,Falco JA,Fisher FR,Tamaki F,Alves E,Wincott CJ,Milne R,Wiedemar N,Craven G,Baragaña B,Wyllie S,Baum J,Baldwin GS,Weerapana E,Tate EW,Child MA

MA5-18268 was used in Western Blotting to develop a CRISPR-based oligo recombineering (CORe) platform to support the rapid identification, functional prioritization and rational targeting of chemically reactive sites in haploid systems and profile the electrophile sensitivity of proteinogenic cysteines in the eukaryotic pathogen Toxoplasma gondii and prioritize functional sites using CORe.

Tue Nov 01 00:00:00 EDT 2022

m6A RNA methylation facilitates pre-mRNA 3'-end formation and is essential for viability of Toxoplasma gondii.

PLoS pathogens

Holmes MJ,Padgett LR,Bastos MS,Sullivan WJ

MA5-18268 was used in Western Blot to establish that the m6A epitranscriptome is essential for parasite viability by contributing to the processing of mRNA 3'-ends.

Thu Jul 01 00:00:00 EDT 2021

Immediate Interferon Gamma Induction Determines Murine Host Compatibility Differences between Toxoplasma gondii and Neospora caninum.

Infection and immunity

Coombs RS,Blank ML,English ED,Adomako-Ankomah Y,Urama IS,Martin AT,Yarovinsky F,Boyle JP

MA5-18268 was used in Western Blotting to identify any differences in the biology of N. caninum profilin compared with that of T. gondii in the immediate production of IFN-y.

Mon Mar 23 00:00:00 EDT 2020

生物信息学

蛋白别名: t gondii; T. gondii; T. gondii SAG1

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