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Tyrosine Hydroxylase Antibody (PA5-143622) in IHC (PFA)
Immunohistochemistry analysis of Tyrosine Hydroxylase in rat brain section. Samples were stained with Tyrosine Hydroxylase polyclonal antibody (Product # PA5-143622) using a dilution of 1:10,000 (red). Costained with mouse mAb to pNF-H (Product # MA5-47473) dilution 1:1,000 in green. The blue is Hoechst staining of nuclear DNA. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post... View More
产品信息
PA5-143622
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Full length human TH expressed in and purified from E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
5mM sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2942851
靶标信息
Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase
基因别名: DYT14; DYT5b; TH; The; TYH
UniProt ID: (Human) P07101, (Mouse) P24529, (Rat) P04177
Entrez Gene ID: (Human) 7054, (Mouse) 21823, (Rat) 25085
tyrosine 3-monooxygenase activity
protein binding
ferrous iron binding
ferric iron binding
amino acid binding
oxygen binding
enzyme binding
protein domain specific binding
tetrahydrobiopterin binding
dopamine binding
monooxygenase activity
iron ion binding
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
metal ion binding
response to hypoxia
synaptic transmission, dopaminergic
dopamine biosynthetic process from tyrosine
heart development
visual perception
learning
memory
mating behavior
locomotory behavior
regulation of heart contraction
aromatic amino acid family metabolic process
organ morphogenesis
aminergic neurotransmitter loading into synaptic vesicle
neurotransmitter biosynthetic process
dopamine biosynthetic process
epinephrine biosynthetic process
norepinephrine biosynthetic process
catecholamine biosynthetic process
eye photoreceptor cell development
eating behavior
response to ethanol
embryonic camera-type eye morphogenesis
oxidation-reduction process
response to amphetamine
heart morphogenesis
fatty acid metabolic process
sphingolipid metabolic process
sensory perception of sound
response to water deprivation
response to light stimulus
response to herbicide
response to salt stress
anatomical structure morphogenesis
response to zinc ion
multicellular organism aging
response to activity
glycoside metabolic process
phthalate metabolic process
cerebral cortex development
response to nutrient levels
response to estradiol
response to lipopolysaccharide
isoquinoline alkaloid metabolic process
social behavior
cellular response to drug
response to isolation stress
response to immobilization stress
terpene metabolic process
circadian sleep/wake cycle
response to peptide hormone
pigmentation
response to ether
response to pyrethroid
response to corticosterone
response to electrical stimulus
phytoalexin metabolic process
cellular response to manganese ion
cellular response to nicotine
cellular response to glucose stimulus
cellular response to growth factor stimulus
response to metal ion
response to organic cyclic compound
response to insecticide
response to nicotine
response to drug
response to steroid hormone
cognition
protein homotetramerization
response to growth factor
cellular response to alkaloid
