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Immunogen sequence: PRGSILATIPE RGTIGVPLIT GMAASEALAP LPFTPNRDRC SWQDLSSKP
Highest antigen sequence identity to the following orthologs - mouse 33%, rat 32%.
RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site. Shows a preference for AGC or AGA. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: FLJ35525; MGC33901; Splicing factor U2AF 26 kDa subunit; U2 auxiliary factor 26; U2 small nuclear RNA auxiliary factor 1-like 3; U2 small nuclear RNA auxiliary factor 1-like 4; U2 small nuclear RNA auxiliary factor 1-like protein 3; U2 small nuclear RNA auxiliary factor 1-like protein 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 3; U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3; U2AF1-like 4; U2AF1-like protein 3
基因别名: U2AF1-RS3; U2AF1L3; U2AF1L3V1; U2AF1L4; U2AF1RS3; U2af26
UniProt ID: (Human) Q8WU68
Entrez Gene ID: (Human) 199746