Proteintech

UBE2C Monoclonal Antibody (1C12H8)

UBE2C Antibody in Immunocytochemistry (ICC/IF)

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UBE2C Antibody (66087-1-IG) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using UBE2C antibody 66087-1-IG at 1:25 dilution and Rhodamine-labeled goat anti-mouse IGG (red).

UBE2C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

66087-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:10-1:100

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Not Applicable

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1C12H8

抗原

UBE2C Fusion Protein Ag19235 (1-179 aa encoded by BC016292)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.84 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MASQNRDPA ATSVAAARKG AEPSGGAARG PVGKRLQQEL MTLMMSGDKG ISAFPESDNL FKWVGTIHGA AGTVYEDLRY KLSLEFPSGY PYNAPTVKFL TPCYHPNVDT QGNICLDILK EKWSALYDVR TILLSIQSLL GEPNIDSPLN THAAELWKNP TAFKKYLQET YSKQVTSQEP (1-179 aa encoded by BC016292)

靶标信息

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Ubiquitin-specific peptidase 14 maintains estrogen receptor α stability via its deubiquitination activity in endometrial cancer.

The Journal of biological chemistry

Su Y,Zeng K,Liu S,Wu Y,Wang C,Wang S,Lin L,Zou R,Sun G,Luan R,Zhou B,Bai Y,Niu J,Zhang Y,Zhao Y

Sun Jan 01 00:00:00 EST 2023

LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.

Cancer letters

Zhai D,Zhang M,Li Y,Bi J,Kuang X,Shan Z,Shao N,Lin Y

Wed Sep 28 00:00:00 EDT 2022

LINC01194 recruits NUMA1 to promote ubiquitination of RYR2 to enhance malignant progression in triple-negative breast cancer.

Cancer letters

Zhai D,Zhang M,Li Y,Bi J,Kuang X,Shan Z,Shao N,Lin Y

Wed Sep 28 00:00:00 EDT 2022

N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.

Cell death & disease

Wang R,Wen P,Yang G,Feng Y,Mi Y,Wang X,Zhu S,Chen YQ

Tue Jul 19 00:00:00 EDT 2022

PRPF6 promotes androgen receptor/androgen receptor-variant 7 actions in castration-resistant prostate cancer cells.

International journal of biological sciences

Liu W,Wang C,Wang S,Zeng K,Wei S,Sun N,Sun G,Wang M,Zou R,Liu W,Lin L,Song H,Jin Z,Zhao Y

Mon Jan 03 00:00:00 EST 2022

Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.

The FEBS journal

Wang X,Yin L,Yang L,Zheng Y,Liu S,Yang J,Cui H,Wang H

Sun Dec 01 00:00:00 EST 2019

Silencing ubiquitin-conjugating enzyme 2C inhibits proliferation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma.

The FEBS journal

Wang X,Yin L,Yang L,Zheng Y,Liu S,Yang J,Cui H,Wang H

Sun Dec 01 00:00:00 EST 2019

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition.

eLife

Hong AL,Tseng YY,Wala JA,Kim WJ,Kynnap BD,Doshi MB,Kugener G,Sandoval GJ,Howard TP,Li J,Yang X,Tillgren M,Ghandi M,Sayeed A,Deasy R,Ward A,McSteen B,Labella KM,Keskula P,Tracy A,Connor C,Clinton CM,Church AJ,Crompton BD,Janeway KA,Van Hare B,Sandak D,Gjoerup O,Bandopadhayay P,Clemons PA,Schreiber SL,Root DE,Gokhale PC,Chi SN,Mullen EA,Roberts CW,Kadoch C,Beroukhim R,Ligon KL,Boehm JS,Hahn WC

Tue Mar 12 00:00:00 EDT 2019

生物信息学

蛋白别名: (E3-independent) E2 ubiquitin-conjugating enzyme C; cyclin-selective ubiquitin carrier protein; E2 ubiquitin-conjugating enzyme C; mitotic-specific ubiquitin-conjugating enzyme; RP3-447F3.1; UbcH10; Ubiquitin carrier protein C; ubiquitin conjugating enzyme E2C; Ubiquitin-conjugating enzyme E2 C; ubiquitin-conjugating enzyme E2C; Ubiquitin-protein ligase C

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基因别名: 1110015A16Rik; D2Ertd695e; dJ447F3.2; UBCH10; UBE2C

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UniProt ID: (Human) O00762, (Mouse) Q9D1C1

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Entrez Gene ID: (Human) 11065, (Rat) 296368, (Mouse) 68612

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功能

ubiquitin-protein transferase activity protein binding ATP binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin conjugating enzyme activity ligase activity ubiquitin-like protein transferase activity nucleotide binding ubiquitin-protein ligase

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