Proteintech

UGDH Polyclonal Antibody

UGDH Antibody in Immunocytochemistry (ICC/IF)

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UGDH Antibody (13151-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed A549 cells using UGDH antibody (Product # 13151-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

UGDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

13151-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看5篇已发表文章 5篇已发表文章

免疫组化 (IHC)

查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200

免疫细胞化学 (ICC/IF)

1:200

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

UGDH Fusion Protein Ag3767 (1-301 aa encoded by BC022781)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MFEIKKICC IGAGYVGGPT CSVIAHMCPE IRVTVVDVNE SRINAWNSPT LPIYEPGLKE VVESCRGKNL FFSTNIDDAI KEADLVFISV NTPTKTYGMG KGRAADLKYI EACARRIVQN SNGYKIVTEK STVPVRAAES IRRIFDANTK PNLNLQVLSN PEFLAEGTAI KDLKNPDRVL IGGDETPEGQ RAVQALCAVY EHWVPREKIL TTNTWSSELS KLAANAFLAQ RISSINSISA LCEATGADVE EVATAIGMDQ RIGNKFLKAS VGFGGSCFQK DVLNLVYLCE ALNLPEVARY WQ (1-301 aa encoded by BC022781)

靶标信息

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis.

Nature communications

Zhang T,Zhang N,Xing J,Zhang S,Chen Y,Xu D,Gu J

Thu May 11 00:00:00 EDT 2023

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.

Nature

Wang X,Liu R,Zhu W,Chu H,Yu H,Wei P,Wu X,Zhu H,Gao H,Liang J,Li G,Yang W

Mon Jul 01 00:00:00 EDT 2019

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

PloS one

Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X

Thu Feb 04 00:00:00 EST 2016

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

PloS one

Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X

Thu Feb 04 00:00:00 EST 2016

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 EST 2014

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 EST 2014

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 EST 2014

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 EST 2014

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 EDT 2015

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 EDT 2015

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 EDT 2015

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 EDT 2015

生物信息学

蛋白别名: UDP UGD; UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogeanse; UDP-glucose dehydrogenase; UDPGDH; uridine diphospho-glucose dehydrogenase

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基因别名: GDH; UDP-GlcDH; UDPGDH; UGD; UGDH

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UniProt ID: (Human) O60701, (Rat) O70199, (Mouse) O70475

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Entrez Gene ID: (Human) 7358, (Rat) 83472, (Mouse) 22235

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功能

UDP-glucose 6-dehydrogenase activity electron carrier activity NAD binding catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor dehydrogenase

参与通路

gastrulation with mouth forming second carbohydrate metabolic process UDP-glucose metabolic process glycosaminoglycan biosynthetic process UDP-glucuronate biosynthetic process oxidation-reduction process metabolic process