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Immunogen sequence: MWDETELGLY KVNEYVDARD TNMGAWFEAQ VVRVTRKAPS RDEPCSSTSR PALEEDVIYH VKYDDYPENG VVQMNSRDVR ARARTIIKWQ DLEVGQVVML NYNPDNPKER GFWYDAEISR KRETRTAREL YANVVLGDDS LNDCRIIFVD EVFKIERPGE; Positive Samples: Mouse brain; Cellular Location: Nucleus
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Ac2-121; E3 ubiquitin-protein ligase UHRF1; FLJ21925; Hnp95 Huhrf1; MGC138707; mUhrf1; Nuclear protein 95; Nuclear zinc finger protein Np95; RING-type E3 ubiquitin transferase UHRF1; ub; Ubiquitin-like PHD and RING finger domain-containing protein 1; Ubiquitin-like-containing PHD and RING finger domains protein 1
基因别名: AL022808; ICBP90; Np95; RNF106; Uhrf1
UniProt ID: (Mouse) Q8VDF2
Entrez Gene ID: (Mouse) 18140
分子生物学功能:
ubiquitin-protein ligase