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Proteintech

UNC13D/Munc13-4 Polyclonal Antibody

6 篇参考文献

查看其他11个Munc13-4抗体

说明书

实验方案

问题与答案

技术支持

货号 16905-1-AP

此产品在中国无法购买

150 µL

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (13)

Application

UNC13D/Munc13-4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 13

UNC13D/Munc13-4 Antibody (16905-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human thymus tissue slide using 16905-1-AP ( UNC13D/Munc13-4 antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

UNC13D/Munc13-4 Antibody in Western Blot (WB)

UNC13D/Munc13-4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

16905-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

UNC13D/Munc13-4 Fusion Protein Ag10519 (1-327 aa encoded by BC067084)

查看免疫原

偶联物

Unconjugated

形式

Liquid

浓度

0.23 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MATLLSHPQ QRPPFLRQAI KIRRRRVRDL QDPPPQMAPE IQPPSHHFSP EQRALLYEDA LYTVLHRLGH PEPNHVTEAS ELLRYLQEAF HVEPEEHQQT LQRVRELEKP IFCLKATVKQ AKGILGKDVS GFSDPYCLLG IEQGVGVPGG SPGSRHRQKA VVRHTIPEEE THRTQVITQT LNPVWDETFI LEFEDITNAS FHLDMWDLDT VESVRQKLGE LTDLHGLRRI FKEARKDKGQ DDFLGNVVLR LQDLRCREDQ WYPLEPRTET YPDRGQCHLQ FQLIHKRRAT SASRSQPSYT VHLHLLQQLV SHEVTQHEAG STSWDGSL (1-327 aa encoded by BC067084)

靶标信息

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells.

Molecular cell

Kurosaki T,Mitsutomi S,Hewko A,Akimitsu N,Maquat LE

Thu Dec 01 00:00:00 UTC 2022

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets.

Frontiers in immunology

Galgano D,Soheili T,Voss M,Torralba-Raga L,Tesi B,Cichocki F,Andre I,Rettig J,Cavazzana M,Bryceson Y

Fri Apr 02 00:00:00 UTC 2021

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 UTC 2014

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 UTC 2014

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.

Blood

Meeths M,Chiang SC,Wood SM,Entesarian M,Schlums H,Bang B,Nordenskjöld E,Björklund C,Jakovljevic G,Jazbec J,Hasle H,Holmqvist BM,Rajic L,Pfeifer S,Rosthøj S,Sabel M,Salmi TT,Stokland T,Winiarski J,Ljunggren HG,Fadeel B,Nordenskjöld M,Henter JI,Bryceson YT

Thu Nov 24 00:00:00 UTC 2011

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.

Blood

Thu Nov 24 00:00:00 UTC 2011

生物信息学

蛋白别名: munc 13-4; Munc13-4; Protein unc-13 homolog D

基因别名: FHL3; HLH3; HPLH3; Munc13-4; UNC13D

UniProt ID: (Human) Q70J99

Entrez Gene ID: (Human) 201294

功能

参与通路

granuloma formation germinal center formation phagocytosis regulation of mast cell degranulation natural killer cell degranulation positive regulation of exocytosis defense response to virus positive regulation of substrate adhesion-dependent cell spreading positive regulation of regulated secretory pathway

UNC13D/Munc13-4 Polyclonal Antibody

UNC13D/Munc13-4 Antibody (16905-1-AP) in IHC (P)

产品信息

16905-1-AP

免疫印迹 (WB)

免疫组化（石蜡） (IHC (P))

免疫细胞化学 (ICC/IF)

免疫沉淀 (IP)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

产品详细信息

靶标信息

生物信息学

功能

参与通路

性能保障

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