Proteintech

USP1 Polyclonal Antibody

USP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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USP1 Antibody (14346-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using (Product # 14346-1-AP) (USP1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP1 Antibody in Immunoprecipitation (IP)

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产品信息

14346-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看22篇已发表文章 22篇已发表文章

免疫组化 (IHC)

查看8篇已发表文章 8篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看7篇已发表文章 7篇已发表文章

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

USP1 Fusion Protein Ag5686 (437-785 aa encoded by BC050525)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.25 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: RTRCLECES LTERREDFQD ISVPVQEDEL SKVEESSEIS PEPKTEMKTL RWAISQFASV ERIVGEDKYF CENCHHYTEA ERSLLFDKMP EVITIHLKCF AASGLEFDCY GGGLSKINTP LLTPLKLSLE EWSTKPTNDS YGLFAVVMHS GITISSGHYT ASVKVTDLNS LELDKGNFVV DQMCEIGKPE PLNEEEARGV VENYNDEEVS IRVGGNTQPS KVLNKKNVEA IGLLGGQKSK ADYELYNKAS NPDKVASTAF AENRNSETSD TTGTHESDRN KESSDQTGIN ISGFENKISY VVQSLKEYEG KWLLFDDSEV KVTEEKDFLN SLSPSTSPTS TPYLLFYKKL (437-785 aa encoded by BC050525)

靶标信息

Deubiquitinating enzymes (DUBs) are capable of producing a free ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins in cells. DUBs possess conserved catalytic regions known as the 'cys domain' and the 'his domain.' There are 2 distinct families of DUBs: ubiquitin-specific processing proteases (UBPs, or USPs) and ubiquitin C-terminal hydrolases (UCHs).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.

Blood advances

Liu S,Xiang Y,Wang B,Gao C,Chen Z,Xie S,Wu J,Liu Y,Zhao X,Yang C,Yue Z,Wang L,Wen X,Zhang R,Zhang F,Xu H,Zhai X,Zheng H,Zhang H,Qian M

Tue Jul 11 00:00:00 EDT 2023

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.

Blood advances

Liu S,Xiang Y,Wang B,Gao C,Chen Z,Xie S,Wu J,Liu Y,Zhao X,Yang C,Yue Z,Wang L,Wen X,Zhang R,Zhang F,Xu H,Zhai X,Zheng H,Zhang H,Qian M

Tue Jul 11 00:00:00 EDT 2023

USP1 promotes the aerobic glycolysis and progression of T-cell acute lymphoblastic leukemia via PLK1/LDHA axis.

Blood advances

Liu S,Xiang Y,Wang B,Gao C,Chen Z,Xie S,Wu J,Liu Y,Zhao X,Yang C,Yue Z,Wang L,Wen X,Zhang R,Zhang F,Xu H,Zhai X,Zheng H,Zhang H,Qian M

Tue Jul 11 00:00:00 EDT 2023

The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion.

Journal of orthopaedic surgery and research

Huang J,Zhou H,He L,Zhong L,Zhou D,Yin Z

Thu Mar 02 00:00:00 EST 2023

The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion.

Journal of orthopaedic surgery and research

Huang J,Zhou H,He L,Zhong L,Zhou D,Yin Z

Thu Mar 02 00:00:00 EST 2023

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

Cell & bioscience

Li Y,Huang X,Jin J,Zhang H,Yang K,Han J,Lv Y,Sun Y,Yao C,Lin T,Zhu C,Liu H

Sat May 06 00:00:00 EDT 2023

Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.

Cell & bioscience

Li Y,Huang X,Jin J,Zhang H,Yang K,Han J,Lv Y,Sun Y,Yao C,Lin T,Zhu C,Liu H

Sat May 06 00:00:00 EDT 2023

Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway.

The Biochemical journal

Hunter JE,Campbell AE,Hannaway NL,Kerridge S,Luli S,Butterworth JA,Sellier H,Mukherjee R,Dhillon N,Sudhindar PD,Shukla R,Brownridge PJ,Bell HL,Coxhead J,Taylor L,Leary P,Hasoon MSR,Collins I,Garrett MD,Eyers CE,Perkins ND

Fri Oct 14 00:00:00 EDT 2022

Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

Annals of hepatology

Chen Z,Ma Y,Guo Z,Song D,Chen Z,Sun M

Fri Apr 15 00:00:00 EDT 2022

Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

Annals of hepatology

Chen Z,Ma Y,Guo Z,Song D,Chen Z,Sun M

Fri Apr 15 00:00:00 EDT 2022

Ubiquitin-specific protease 1 acts as an oncogene and promotes lenvatinib efficacy in hepatocellular carcinoma by stabilizing c-kit.

Annals of hepatology

Chen Z,Ma Y,Guo Z,Song D,Chen Z,Sun M

Fri Apr 15 00:00:00 EDT 2022

HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Huang Z,Chen Y,Chen R,Zhou B,Wang Y,Hong L,Wang Y,Wang J,Xu X,Huang Z,Chen W

Wed Nov 16 00:00:00 EST 2022

HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Huang Z,Chen Y,Chen R,Zhou B,Wang Y,Hong L,Wang Y,Wang J,Xu X,Huang Z,Chen W

Wed Nov 16 00:00:00 EST 2022

HPV Enhances HNSCC Chemosensitization by Inhibiting SERPINB3 Expression to Disrupt the Fanconi Anemia Pathway.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Huang Z,Chen Y,Chen R,Zhou B,Wang Y,Hong L,Wang Y,Wang J,Xu X,Huang Z,Chen W

Wed Nov 16 00:00:00 EST 2022

CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.

Theranostics

Tyagi A,Kaushal K,Chandrasekaran AP,Sarodaya N,Das S,Park CH,Hong SH,Kim KS,Ramakrishna S

Tue Aug 16 00:00:00 EDT 2022

CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.

Theranostics

Tyagi A,Kaushal K,Chandrasekaran AP,Sarodaya N,Das S,Park CH,Hong SH,Kim KS,Ramakrishna S

Tue Aug 16 00:00:00 EDT 2022

CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.

Theranostics

Tyagi A,Kaushal K,Chandrasekaran AP,Sarodaya N,Das S,Park CH,Hong SH,Kim KS,Ramakrishna S

Tue Aug 16 00:00:00 EDT 2022

CRISPR/Cas9-based genome-wide screening for deubiquitinase subfamily identifies USP1 regulating MAST1-driven cisplatin-resistance in cancer cells.

Theranostics

Tyagi A,Kaushal K,Chandrasekaran AP,Sarodaya N,Das S,Park CH,Hong SH,Kim KS,Ramakrishna S

Tue Aug 16 00:00:00 EDT 2022

Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC.

Cell death & disease

Wang L,Hu T,Shen Z,Zheng Y,Geng Q,Li L,Sha B,Li M,Sun Y,Guo Y,Xue W,Xuan D,Chen P,Zhao J

Thu Nov 10 00:00:00 EST 2022

Inhibition of USP1 activates ER stress through Ubi-protein aggregation to induce autophagy and apoptosis in HCC.

Cell death & disease

Wang L,Hu T,Shen Z,Zheng Y,Geng Q,Li L,Sha B,Li M,Sun Y,Guo Y,Xue W,Xuan D,Chen P,Zhao J

Thu Nov 10 00:00:00 EST 2022

H3F3A K27M Mutation Promotes the Infiltrative Growth of High-Grade Glioma in Adults by Activating β-Catenin/USP1 Signaling.

Cancers

Sun Z,Zhu Y,Feng X,Liu X,Zhou K,Wang Q,Zhang H,Shi H

Mon Oct 03 00:00:00 EDT 2022

FANCD2 promotes the malignant behavior of endometrial cancer cells and its prognostic value.

Experimental cell research

Zheng C,Ren Z,Chen H,Yuan X,Suye S,Yin H,Zhou Z,Fu C

Thu Dec 15 00:00:00 EST 2022

USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.

Journal of musculoskeletal & neuronal interactions

Sun D,Peng Y,Ge S,Fu Q

Thu Dec 01 00:00:00 EST 2022

USP1 Inhibits NF-κB/NLRP3 Induced Pyroptosis through TRAF6 in Osteoblastic MC3T3-E1 Cells.

Journal of musculoskeletal & neuronal interactions

Sun D,Peng Y,Ge S,Fu Q

Thu Dec 01 00:00:00 EST 2022

USP1-WDR48 deubiquitinase complex enhances TGF-β induced epithelial-mesenchymal transition of TNBC cells via stabilizing TAK1.

Cell cycle (Georgetown, Tex.)

Han D,Wang L,Chen B,Zhao W,Liang Y,Li Y,Zhang H,Liu Y,Wang X,Chen T,Li C,Song X,Luo D,Li Z,Yang Q

Mon Feb 01 00:00:00 EST 2021

USP1 Promotes GC Metastasis via Stabilizing ID2.

Disease markers

Li N,Wu L,Zuo X,Luo H,Sheng Y,Yan J

Wed Mar 09 00:00:00 EST 2022

USP1 Promotes GC Metastasis via Stabilizing ID2.

Disease markers

Li N,Wu L,Zuo X,Luo H,Sheng Y,Yan J

Wed Mar 09 00:00:00 EST 2022

USP1 Promotes GC Metastasis via Stabilizing ID2.

Disease markers

Li N,Wu L,Zuo X,Luo H,Sheng Y,Yan J

Wed Mar 09 00:00:00 EST 2022

Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.

Cell proliferation

Zhao Y,Xue C,Xie Z,Ouyang X,Li L

Thu Oct 01 00:00:00 EDT 2020

Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma.

Cell proliferation

Zhao Y,Xue C,Xie Z,Ouyang X,Li L

Thu Oct 01 00:00:00 EDT 2020

USP1 Maintains the Survival of Liver Circulating Tumor Cells by Deubiquitinating and Stabilizing TBLR1.

Frontiers in oncology

Li Y,Xu Y,Gao C,Sun Y,Zhou K,Wang P,Cheng J,Guo W,Ya C,Fan J,Yang X

Wed Oct 28 00:00:00 EDT 2020

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma.

Nature communications

Herviou P,Le Bras M,Dumas L,Hieblot C,Gilhodes J,Cioci G,Hugnot JP,Ameadan A,Guillonneau F,Dassi E,Cammas A,Millevoi S

Wed May 27 00:00:00 EDT 2020

USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.

EMBO reports

Goldbraikh D,Neufeld D,Eid-Mutlak Y,Lasry I,Gilda JE,Parnis A,Cohen S

Fri Apr 03 00:00:00 EDT 2020

USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.

Oncogene

Ma A,Tang M,Zhang L,Wang B,Yang Z,Liu Y,Xu G,Wu L,Jing T,Xu X,Yang S,Liu Y

Fri Mar 01 00:00:00 EST 2019

USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.

Oncogene

Ma A,Tang M,Zhang L,Wang B,Yang Z,Liu Y,Xu G,Wu L,Jing T,Xu X,Yang S,Liu Y

Fri Mar 01 00:00:00 EST 2019

USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.

Oncogene

Ma A,Tang M,Zhang L,Wang B,Yang Z,Liu Y,Xu G,Wu L,Jing T,Xu X,Yang S,Liu Y

Fri Mar 01 00:00:00 EST 2019

USP1 inhibition destabilizes KPNA2 and suppresses breast cancer metastasis.

Oncogene

Ma A,Tang M,Zhang L,Wang B,Yang Z,Liu Y,Xu G,Wu L,Jing T,Xu X,Yang S,Liu Y

Fri Mar 01 00:00:00 EST 2019

USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.

Cancer immunology research

Huang X,Zhang Q,Lou Y,Wang J,Zhao X,Wang L,Zhang X,Li S,Zhao Y,Chen Q,Liang T,Bai X

Tue Oct 01 00:00:00 EDT 2019

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.

Nature communications

Ha K,Ma C,Lin H,Tang L,Lian Z,Zhao F,Li JM,Zhen B,Pei H,Han S,Malumbres M,Jin J,Chen H,Zhao Y,Zhu Q,Zhang P

Mon Jun 12 00:00:00 EDT 2017

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.

Nature communications

Ha K,Ma C,Lin H,Tang L,Lian Z,Zhao F,Li JM,Zhen B,Pei H,Han S,Malumbres M,Jin J,Chen H,Zhao Y,Zhu Q,Zhang P

Mon Jun 12 00:00:00 EDT 2017

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.

Nature communications

Ha K,Ma C,Lin H,Tang L,Lian Z,Zhao F,Li JM,Zhen B,Pei H,Han S,Malumbres M,Jin J,Chen H,Zhao Y,Zhu Q,Zhang P

Mon Jun 12 00:00:00 EDT 2017

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.

Nature communications

Ha K,Ma C,Lin H,Tang L,Lian Z,Zhao F,Li JM,Zhen B,Pei H,Han S,Malumbres M,Jin J,Chen H,Zhao Y,Zhu Q,Zhang P

Mon Jun 12 00:00:00 EDT 2017

USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.

Biochemical and biophysical research communications

Xiao H,Tian Y,Yang Y,Hu F,Xie X,Mei J,Ding F

Fri May 08 00:00:00 EDT 2015

USP22 acts as an oncogene by regulating the stability of cyclooxygenase-2 in non-small cell lung cancer.

Biochemical and biophysical research communications

Xiao H,Tian Y,Yang Y,Hu F,Xie X,Mei J,Ding F

Fri May 08 00:00:00 EDT 2015

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

Nature chemical biology

Liang Q,Dexheimer TS,Zhang P,Rosenthal AS,Villamil MA,You C,Zhang Q,Chen J,Ott CA,Sun H,Luci DK,Yuan B,Simeonov A,Jadhav A,Xiao H,Wang Y,Maloney DJ,Zhuang Z

Tue Apr 01 00:00:00 EDT 2014

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

Nature chemical biology

Liang Q,Dexheimer TS,Zhang P,Rosenthal AS,Villamil MA,You C,Zhang Q,Chen J,Ott CA,Sun H,Luci DK,Yuan B,Simeonov A,Jadhav A,Xiao H,Wang Y,Maloney DJ,Zhuang Z

Tue Apr 01 00:00:00 EDT 2014

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

Molecular cell

Ciccia A,Nimonkar AV,Hu Y,Hajdu I,Achar YJ,Izhar L,Petit SA,Adamson B,Yoon JC,Kowalczykowski SC,Livingston DM,Haracska L,Elledge SJ

Fri Aug 10 00:00:00 EDT 2012

Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.

Molecular cell

Ciccia A,Nimonkar AV,Hu Y,Hajdu I,Achar YJ,Izhar L,Petit SA,Adamson B,Yoon JC,Kowalczykowski SC,Livingston DM,Haracska L,Elledge SJ

Fri Aug 10 00:00:00 EDT 2012

生物信息学

蛋白别名: Deubiquitinating enzyme 1; hUBP; ubiquitin carboxyl terminal hydrolase 1; Ubiquitin carboxyl-terminal hydrolase 1; ubiquitin specific processing protease 1; ubiquitin specific protease 1; Ubiquitin thioesterase 1; ubiquitin thiolesterase 1; Ubiquitin-specific-processing protease 1

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基因别名: UBP; USP1

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UniProt ID: (Human) O94782

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Entrez Gene ID: (Human) 7398

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功能

cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding cysteine protease

参与通路

skeletal system development regulation of DNA repair ubiquitin-dependent protein catabolic process response to UV protein deubiquitination monoubiquitinated protein deubiquitination interstrand cross-link repair DNA damage response, detection of DNA damage