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产品信息
A300-900A-T
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 50 and 100 of Human Ubiquitin Specific Peptidase 10.
偶联物
Unconjugated
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
靶标信息
USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 10; MGC2621; ubiquintin c-terminal hydrolase related polypeptide; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10
基因别名: 2610014N07Rik; KIAA0190; mKIAA0190; Ode-1; UBPO; Uchrp; USP10
UniProt ID: (Human) Q14694, (Mouse) P52479
Entrez Gene ID: (Human) 9100, (Mouse) 22224
DNA repair
proteolysis
ubiquitin-dependent protein catabolic process
autophagy
cellular response to DNA damage stimulus
regulation of autophagy
protein deubiquitination
DNA damage response, signal transduction by p53 class mediator
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
translesion synthesis
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
