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产品信息
PA5-85219
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human USP10.
偶联物
Unconjugated
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2792362
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (95%), Rat (97%), Xenopus laevis (93%), Chicken (94%), Bovine (98%).
Positive Control: HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Deubiquitinating enzyme 10; MGC2621; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10
基因别名: KIAA0190; UBPO; USP10
UniProt ID: (Human) Q14694
Entrez Gene ID: (Human) 9100
ubiquitin-dependent protein catabolic process
autophagy
cellular response to DNA damage stimulus
regulation of autophagy
protein deubiquitination
translesion synthesis
DNA damage response, signal transduction by p53 class mediator
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
