Proteintech

USP11 Polyclonal Antibody

USP11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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USP11 Antibody (10244-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 10244-1-AP ( USP11 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

USP11 Antibody in Immunoprecipitation (IP)

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产品信息

10244-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看8篇已发表文章 8篇已发表文章

免疫组化 (IHC)

查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫沉淀 (IP)

0.5-4.0 µg

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

USP11 Fusion Protein Ag0296 (55-567 aa encoded by BC000350)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: RAGESWFLV EKHWYKQWEA YVQGGDQDSS TFPGCINNAT LFQDEINWRL KEGLVEGEDY VLLPAAAWHY LVSWYGLEHG QPPIERKVIE LPNIQKVEVY PVELLLVRHN DLGKSHTVQF SHTDSIGLVL RTARERFLVE PQEDTRLWAK NSEGSLDRLY DTHITVLDAA LETGQLIIME TRKKDGTWPS AQLHVMNNNM SEEDEDFKGQ PGICGLTNLG NTCFMNSALQ CLSNVPQLTE YFLNNCYLEE LNFRNPLGMK GEIAEAYADL VKQAWSGHHR SIVPHVFKNK VGHFASQFLG YQQHDSQELL SFLLDGLHED LNRVKKKEYV ELCDAAGRPD QEVAQEAWQN HKRRNDSVIV DTFHGLFKST LVCPDCGNVS VTFDPFCYLS VPLLISHKRV LEVFFIPMDP RRKPEQHRLV VPKKGKISDL CVALSKHTGI SPERMMVADV FSHRFYKLYQ LEEPLSSILD RDDIFVYEVS GRIEAIEGSR EDIVVPVYLR ERTPARDYNN SYYG (55-567 aa encoded by BC000350)

靶标信息

USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway.

Cancer letters

Qiao L,Zhang Q,Sun Z,Liu Q,Wu Z,Hu W,Bao S,Yang Q,Liu L

Sat Aug 28 00:00:00 UTC 2021

The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway.

Cancer letters

Qiao L,Zhang Q,Sun Z,Liu Q,Wu Z,Hu W,Bao S,Yang Q,Liu L

Sat Aug 28 00:00:00 UTC 2021

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.

Nature cell biology

Adamowicz M,Hailstone R,Demin AA,Komulainen E,Hanzlikova H,Brazina J,Gautam A,Wells SE,Caldecott KW

Wed Dec 01 00:00:00 UTC 2021

The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.

Oncogene

Meng C,Zhan J,Chen D,Shao G,Zhang H,Gu W,Luo J

Mon Mar 01 00:00:00 UTC 2021

A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis.

Theranostics

Zhang Q,Cao C,Gong W,Bao K,Wang Q,Wang Y,Bi L,Ma S,Zhao J,Liu L,Tian S,Zhang K,Yang J,Yao Z,Song N,Shi L

Mon May 31 00:00:00 UTC 2021

CRL4^DCAF8 and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs).

Biochemical and biophysical research communications

Huang D,Liu C,Sun X,Sun X,Qu Y,Tang Y,Li G,Tong T

Thu Aug 20 00:00:00 UTC 2020

Aberrant USP11 expression regulates NF90 to promote proliferation and metastasis in hepatocellular carcinoma.

American journal of cancer research

Zhang C,Xie C,Wang X,Huang Y,Gao S,Lu J,Lu Y,Zhang S

Mon Sep 28 00:00:00 UTC 2020

Aberrant USP11 expression regulates NF90 to promote proliferation and metastasis in hepatocellular carcinoma.

American journal of cancer research

Zhang C,Xie C,Wang X,Huang Y,Gao S,Lu J,Lu Y,Zhang S

Mon Sep 28 00:00:00 UTC 2020

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.

Clinical and translational medicine

Zhao H,Wang Y,Yang C,Zhou J,Wang L,Yi K,Li Y,Wang Q,Shi J,Kang C,Zeng L

Tue Jan 28 00:00:00 UTC 2020

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.

Clinical and translational medicine

Zhao H,Wang Y,Yang C,Zhou J,Wang L,Yi K,Li Y,Wang Q,Shi J,Kang C,Zeng L

Tue Jan 28 00:00:00 UTC 2020

Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein.

American journal of cancer research

Zhang E,Shen B,Mu X,Qin Y,Zhang F,Liu Y,Xiao J,Zhang P,Wang C,Tan M,Fan Y

Thu Oct 01 00:00:00 UTC 2020

Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein.

American journal of cancer research

Zhang E,Shen B,Mu X,Qin Y,Zhang F,Liu Y,Xiao J,Zhang P,Wang C,Tan M,Fan Y

Thu Oct 01 00:00:00 UTC 2020

Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.

Oncotarget

Lim KH,Suresh B,Park JH,Kim YS,Ramakrishna S,Baek KH

Tue Mar 22 00:00:00 UTC 2016

Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.

Oncotarget

Lim KH,Suresh B,Park JH,Kim YS,Ramakrishna S,Baek KH

Tue Mar 22 00:00:00 UTC 2016

生物信息学

蛋白别名: deubiquitinating enzyme 11; RP4-659F15.2; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin-specific-processing protease 11

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基因别名: UHX1

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Entrez Gene ID: (Human) 8237

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功能

cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding cysteine protease

参与通路

ubiquitin-dependent protein catabolic process protein deubiquitination