Proteintech

USP2 Polyclonal Antibody

17 篇参考文献

查看其他9个USP2抗体

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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USP2 Antibody (10392-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue slide using (Product # 10392-1-AP) USP2 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

USP2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

USP2 Antibody in Western Blot (WB)

Product Image Gallery

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue slide using (Product # 10392-1-AP) USP2 antibody at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue slide using (Product # 10392-1-AP) USP2 antibody at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human prostate cancer using 10392-1-AP (USP2 antibody) at dilution of 1:100 (under 25x lens).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human skeletal muscle using 10392-1-AP (USP2 antibody) at dilution of 1:50 (under 40x lens).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human skeletal muscle using 10392-1-AP (USP2 antibody) at dilution of 1:50 (under 10x lens).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 10392-1-AP (USP2 antibody) at dilution of 1:50 (under 40x lens).

USP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer using 10392-1-AP (USP2 antibody) at dilution of 1:50 (under 10x lens).

USP2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA)) — Immunofluorescent analysis of ( 4% PFA) fixed mouse embryo tissue using 10392-1-AP (USP2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

USP2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA)) — Immunofluorescent analysis of ( 4% PFA) fixed mouse embryo tissue using 10392-1-AP (USP2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

USP2 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 10392-1-AP) USP2 antibody at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — Various lysates were subjected to SDS PAGE followed by western blot with (Product # 10392-1-AP) USP2 antibody at dilution of 1:1,000 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — Mouse kidney tissue were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — Rat brain tissue were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 Antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — MCF7 cells were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

USP2 Antibody in Western Blot (WB) — MCF7 cells were subjected to SDS PAGE followed by western blot with 10392-1-AP (USP2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

产品信息

10392-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看10篇已发表文章 10篇已发表文章

免疫组化 (IHC)

-

查看5篇已发表文章 5篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:500

-

免疫细胞化学 (ICC/IF)

1:50-1:500

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

-

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

USP2 Fusion Protein Ag0591 (11-241 aa encoded by BC002955)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.27 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody is specific to the isoform 1 (USP2a) of USP2.

Immunogen sequence: YTESARYTD AHYAKSGYGA YTPSSYGANL AASLLEKEKL GFKPVPTSSF LTRPRTYGPS SLLDYDRGRP LLRPDITGGG KRAESQTRGT ERPLGSGLSG GSGFPYGVTN NCLSYLPINA YDQGVTLTQK LDSQSDLARD FSSLRTSDSY RIDPRNLGRS PMLARTRKEL CTLQGLYQTA SCPEYLVDYL ENYGRKGSAS QVPSQAPPSR VPEIISPTYR PIGRYTLWET GK (11-241 aa encoded by BC002955)

靶标信息

Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Journal of cancer research and clinical oncology

Wei C,Zhao X,Zhang H,Wang L

Fri Sep 01 00:00:00 EDT 2023

USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Journal of cancer research and clinical oncology

Wei C,Zhao X,Zhang H,Wang L

Fri Sep 01 00:00:00 EDT 2023

USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Journal of cancer research and clinical oncology

Wei C,Zhao X,Zhang H,Wang L

Fri Sep 01 00:00:00 EDT 2023

USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Journal of cancer research and clinical oncology

Wei C,Zhao X,Zhang H,Wang L

Fri Sep 01 00:00:00 EDT 2023

USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Journal of cancer research and clinical oncology

Wei C,Zhao X,Zhang H,Wang L

Fri Sep 01 00:00:00 EDT 2023

USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail.

Journal of cancer research and clinical oncology

Wei C,Zhao X,Zhang H,Wang L

Fri Sep 01 00:00:00 EDT 2023

Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.

Bioengineered

Duan J,Jin M,Yang D,Shi J,Gao J,Guo D,Tang H,Zhang S,Qiao B

Tue Feb 01 00:00:00 EST 2022

Ubiquitin-specific peptidase 2 inhibits epithelial-mesenchymal transition in clear cell renal cell carcinoma metastasis by downregulating the NF-κB pathway.

Bioengineered

Duan J,Jin M,Yang D,Shi J,Gao J,Guo D,Tang H,Zhang S,Qiao B

Tue Feb 01 00:00:00 EST 2022

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Cell death discovery

Han Z,Liu M,Xie Y,Zeng K,Zhan Z,Chen Y,Wang L,Chen X,Luo Y,Zeng Y,Zhan H,Lin Y,Zhang K,Zhu X,Liu S,Luo X,Zhou A

Fri Nov 04 00:00:00 EDT 2022

Ubiquitin-specific protease 2 regulates Ang Ⅱ-induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing β-catenin in vitro.

Journal of cellular and molecular medicine

Xu Q,Liu M,Zhang F,Liu X,Ling S,Chen X,Gu J,Ou W,Liu S,Liu N

Fri Jan 01 00:00:00 EST 2021

Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30.

Cell death discovery

Yan D,Li X,Yang Q,Huang Q,Yao L,Zhang P,Sun W,Lin S,Dou QP,Liu J,Chen X

Wed Aug 11 00:00:00 EDT 2021

Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.

Mediators of inflammation

Xing J,Li P,Hong J,Wang M,Liu Y,Gao Y,Dong J,Gu H,Li L

Mon Aug 02 00:00:00 EDT 2021

Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.

Mediators of inflammation

Xing J,Li P,Hong J,Wang M,Liu Y,Gao Y,Dong J,Gu H,Li L

Mon Aug 02 00:00:00 EDT 2021

Inhibition of USP2 eliminates cancer stem cells and enhances TNBC responsiveness to chemotherapy.

Cell death & disease

He J,Lee HJ,Saha S,Ruan D,Guo H,Chan CH

Thu Mar 28 00:00:00 EDT 2019

3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.

Molecular nutrition & food research

Yang H,Seo SG,Shin SH,Min S,Kang MJ,Yoo R,Kwon JY,Yue S,Kim KH,Cheng JX,Kim JR,Park JS,Kim JH,Park JHY,Lee HJ,Lee KW

Sun Oct 01 00:00:00 EDT 2017

3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.

Molecular nutrition & food research

Yang H,Seo SG,Shin SH,Min S,Kang MJ,Yoo R,Kwon JY,Yue S,Kim KH,Cheng JX,Kim JR,Park JS,Kim JH,Park JHY,Lee HJ,Lee KW

Sun Oct 01 00:00:00 EDT 2017

CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans.

BioMed research international

Kwon DN,Choi YJ,Cho SG,Park C,Seo HG,Song H,Kim JH

Mon Aug 29 00:00:00 EDT 2016

CMP-Neu5Ac Hydroxylase Null Mice as a Model for Studying Metabolic Disorders Caused by the Evolutionary Loss of Neu5Gc in Humans.

BioMed research international

Kwon DN,Choi YJ,Cho SG,Park C,Seo HG,Song H,Kim JH

Mon Aug 29 00:00:00 EDT 2016

USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Qu Q,Mao Y,Xiao G,Fei X,Wang J,Zhang Y,Liu J,Cheng G,Chen X,Wang J,Shen K

Wed Jul 01 00:00:00 EDT 2015

USP2 promotes cell migration and invasion in triple negative breast cancer cell lines.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Qu Q,Mao Y,Xiao G,Fei X,Wang J,Zhang Y,Liu J,Cheng G,Chen X,Wang J,Shen K

Wed Jul 01 00:00:00 EDT 2015

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kitamura H,Kimura S,Shimamoto Y,Okabe J,Ito M,Miyamoto T,Naoe Y,Kikuguchi C,Meek B,Toda C,Okamoto S,Kanehira K,Hase K,Watarai H,Ishizuka M,El-Osta A,Ohara O,Miyoshi I

Sun Dec 01 00:00:00 EST 2013

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kitamura H,Kimura S,Shimamoto Y,Okabe J,Ito M,Miyamoto T,Naoe Y,Kikuguchi C,Meek B,Toda C,Okamoto S,Kanehira K,Hase K,Watarai H,Ishizuka M,El-Osta A,Ohara O,Miyoshi I

Sun Dec 01 00:00:00 EST 2013

Expression of USP2-69 in mesangial cells in vivo and in vitro.

Pathology international

Wang S,Wu H,Liu Y,Sun J,Zhao Z,Chen Q,Guo M,Ma D,Zhang Z

Mon Mar 01 00:00:00 EST 2010

Expression of USP2-69 in mesangial cells in vivo and in vitro.

Pathology international

Wang S,Wu H,Liu Y,Sun J,Zhao Z,Chen Q,Guo M,Ma D,Zhang Z

Mon Mar 01 00:00:00 EST 2010

Expression of USP2-69 in mesangial cells in vivo and in vitro.

Pathology international

Wang S,Wu H,Liu Y,Sun J,Zhao Z,Chen Q,Guo M,Ma D,Zhang Z

Mon Mar 01 00:00:00 EST 2010

Expression of USP2-69 in mesangial cells in vivo and in vitro.

Pathology international

Wang S,Wu H,Liu Y,Sun J,Zhao Z,Chen Q,Guo M,Ma D,Zhang Z

Mon Mar 01 00:00:00 EST 2010

生物信息学

蛋白别名: 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific protease 12; ubiquitin specific protease 2; ubiquitin specific protease 9; Ubiquitin thioesterase 2; ubiquitin thiolesterase 2; Ubiquitin-specific-processing protease 2; Ubiquitin-specific-processing protease testis; UBP-t

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基因别名: B930035K21Rik; MNCb-0190; UBP-t; UBP41; Ubp69; USP2; USP9

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UniProt ID: (Human) O75604, (Mouse) O88623, (Rat) Q5U349

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Entrez Gene ID: (Human) 9099, (Mouse) 53376, (Rat) 115771

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cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding cyclin binding ubiquitin protein ligase binding identical protein binding metal ion binding peptidase activity cysteine-type peptidase activity hydrolase activity thiol-dependent ubiquitinyl hydrolase activity cysteine protease

参与通路

negative regulation of transcription from RNA polymerase II promoter ubiquitin-dependent protein catabolic process cell cycle muscle organ development protein deubiquitination circadian regulation of gene expression entrainment of circadian clock by photoperiod locomotor rhythm positive regulation of mitotic cell cycle circadian behavior negative regulation of skeletal muscle tissue development positive regulation of skeletal muscle tissue development protein stabilization regulation of transcription, DNA-templated proteolysis proteasome-mediated ubiquitin-dependent protein catabolic process rhythmic process regulation of proteasomal protein catabolic process