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Immunogen sequence: LKNVGNTCW FSAVIQSLFN LLEFRRLVLN YKPPSNAQDL PRNQKEHRNL PFMRELRYLF ALLVGTKRKY VDPSRAVEIL KDAFKSNDSQ QEWHQDYRKF RETTMYLIIG LENFQRESYI DSLLFLICAY QNNKELLSKG LYRGHDEELI SHYRRECLLK LNEQAAELFE SGEDREVNNG LIIMNEFIVP FLPLLLVDEM EEKDILAVED MRNRWCSYLG QEMEPHLQEK LTDFLPKLLD CSMEIKSFHE PPKLPSYSTH ELCERFARIM LSLSRTPADG R (171-451 aa encoded by BC015930)
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Deubiquitinating enzyme 25; mUSP25; Ubiquitin carboxyl-terminal hydrolase 25; ubiquitin specific protease 25; Ubiquitin thioesterase 25; ubiquitin thiolesterase 25; ubiquitin-specific processing protease 25; Ubiquitin-specific-processing protease 25; USP on chromosome 21
基因别名: USP21; USP25
UniProt ID: (Human) Q9UHP3, (Mouse) P57080
Entrez Gene ID: (Human) 29761, (Mouse) 30940