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The antibody recognize all 3 isoforms of USP34.
Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Deubiquitinating enzyme 34; U2af1-rs1 region 2; Ubiquitin carboxyl-terminal hydrolase 34; ubiquitin specific protease 34; Ubiquitin thioesterase 34; ubiquitin thiolesterase 34; Ubiquitin-specific-processing protease 34
基因别名: A530081C03Rik; KIAA0570; KIAA0729; Murr2; USP34
UniProt ID: (Human) Q70CQ2, (Mouse) Q6ZQ93
Entrez Gene ID: (Human) 9736, (Mouse) 17847
分子生物学功能: cysteine protease non-receptor serine/threonine protein kinase protein modifying enzyme