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Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.
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蛋白别名: ubinuclein 1; Ubinuclein-2; UBN1; VT; VT4
基因别名: 2900060J04Rik; 6030408G03Rik; BC060116; D130059P03Rik; KIAA2030; mKIAA2030; UBN2
UniProt ID: (Human) Q6ZU65, (Mouse) Q80WC1
Entrez Gene ID: (Human) 254048, (Mouse) 320538
分子生物学功能:
scaffold/adaptor protein