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产品信息
ANR-007-200UL
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
GST fusion protein with the sequence SATAATVPPAAPAGEGGPPAPPPNLT, corresponding to amino acid residues 2-27 of rat VAMP2, Cytoplasmic, N-terminus
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 5% sucrose, 1% BSA
内含物
0.025% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It is suggested that VAMP-2 is a resident protein of the insulin-sensitive glucose transporter type 4 (GLUT4) compartment and that it is required for GLUT4 vesicle incorporation into the cell surface in response to insulin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Synaptobrevin 2 (vesicle-associated membrane protein VAMP-2); synaptobrevin II; Synaptobrevin-2; vamp; VAMP-2; vesicle-associated membrane 2; Vesicle-associated membrane protein (synaptobrevin 2); Vesicle-associated membrane protein 2
基因别名: RATVAMPB; RATVAMPIR; SYB; Syb-2; Syb2; sybII; Vamp2
UniProt ID: (Mouse) P63044, (Rat) P63045
Entrez Gene ID: (Mouse) 22318, (Rat) 24803
protein complex assembly
vesicle fusion
response to glucose
protein transport
synaptic vesicle exocytosis
vesicle-mediated transport
calcium ion regulated exocytosis
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
cellular response to insulin stimulus
Golgi to plasma membrane protein transport
eosinophil degranulation
long-term synaptic potentiation
regulation of vesicle-mediated transport
membrane fusion
positive regulation of intracellular protein transport
regulation of delayed rectifier potassium channel activity
neurotransmitter secretion
neutrophil degranulation
natural killer cell degranulation
mucus secretion
regulation of histamine secretion by mast cell
