Proteintech

VANGL2 Polyclonal Antibody

VANGL2 Antibody in Immunocytochemistry (ICC/IF)

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VANGL2 Antibody (21492-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 21492-1-AP (VANGL2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

VANGL2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

VANGL2 Antibody in Immunoprecipitation (IP)

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产品信息

21492-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看7篇已发表文章 7篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

免疫细胞化学 (ICC/IF)

1:20-1:200

查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

VANGL2 Fusion Protein Ag15833 (268-322 aa encoded by BC103920)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.23 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: IQRVAVWIL EKYYHDFPVY NPALLNLPKS VLAKKVSGFK VYSLGEENST NNSTGQ (268-322 aa encoded by BC103920)

靶标信息

Van Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acidprotein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-disheveled tissue polarity pathway. It interacts through it's C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumor suppressor. It ispredominantly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis.

Breast cancer research : BCR

VanderVorst K,Dreyer CA,Hatakeyama J,Bell GRR,Learn JA,Berg AL,Hernandez M,Lee H,Collins SR,Carraway KL

Fri May 05 00:00:00 EDT 2023

Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis.

Breast cancer research : BCR

VanderVorst K,Dreyer CA,Hatakeyama J,Bell GRR,Learn JA,Berg AL,Hernandez M,Lee H,Collins SR,Carraway KL

Fri May 05 00:00:00 EDT 2023

A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties.

Cancer letters

Dreyer CA,VanderVorst K,Natwick D,Bell G,Sood P,Hernandez M,Angelastro JM,Collins SR,Carraway KL

Fri Jul 28 00:00:00 EDT 2023

A complex of Wnt/planar cell polarity signaling components Vangl1 and Fzd7 drives glioblastoma multiforme malignant properties.

Cancer letters

Dreyer CA,VanderVorst K,Natwick D,Bell G,Sood P,Hernandez M,Angelastro JM,Collins SR,Carraway KL

Fri Jul 28 00:00:00 EDT 2023

Dihydroartemisinin Attenuates Hypoxic Pulmonary Hypertension via the Downregulation of miR-335 Targeting Vangl2.

DNA and cell biology

Li Y,Cai H,Wei J,Zhu L,Yao Y,Xie M,Song L,Zhang C,Huang X,Wang L

Mon Aug 01 00:00:00 EDT 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.

Cell and tissue research

Sheng X,Gao S,Sheng Y,Xie X,Wang J,He Y

Sat Jan 01 00:00:00 EST 2022

CIC missense variants contribute to susceptibility for spina bifida.

Human mutation

Han X,Cao X,Aguiar-Pulido V,Yang W,Karki M,Ramirez PAP,Cabrera RM,Lin YL,Wlodarczyk BJ,Shaw GM,Ross ME,Zhang C,Finnell RH,Lei Y

Thu Dec 01 00:00:00 EST 2022

Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.

Developmental cell

Gong Y,Li Z,Zou S,Deng D,Lai P,Hu H,Yao Y,Hu L,Zhang S,Li K,Wei T,Zhao X,Xiao G,Chen Z,Jiang Y,Bai X,Zou Z

Mon Jul 26 00:00:00 EDT 2021

Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells.

Developmental cell

Gong Y,Li Z,Zou S,Deng D,Lai P,Hu H,Yao Y,Hu L,Zhang S,Li K,Wei T,Zhao X,Xiao G,Chen Z,Jiang Y,Bai X,Zou Z

Mon Jul 26 00:00:00 EDT 2021

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.

Chinese medical journal

Duan HY,Zhou KY,Wang T,Zhang Y,Li YF,Hua YM,Wang C

Wed Sep 05 00:00:00 EDT 2018

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.

Chinese medical journal

Duan HY,Zhou KY,Wang T,Zhang Y,Li YF,Hua YM,Wang C

Wed Sep 05 00:00:00 EDT 2018

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.

Chinese medical journal

Duan HY,Zhou KY,Wang T,Zhang Y,Li YF,Hua YM,Wang C

Wed Sep 05 00:00:00 EDT 2018

VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.

Experimental cell research

Jessen TN,Jessen JR

Fri Dec 15 00:00:00 EST 2017

VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix.

Experimental cell research

Jessen TN,Jessen JR

Fri Dec 15 00:00:00 EST 2017

生物信息学

蛋白别名: loop tail associated protein; Loop-tail protein 1; Loop-tail protein 1 homolog; Loop-tail-associated protein; MGC119403; MGC119404; Strabismus 1; Van Gogh-like protein 2; vang; vang (van gogh)-like 2; vang-like 2 (van gogh, Drosophila); Vang-like protein 2; vangl2 {ECO:0000312|RGD:1309442}

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基因别名: C530001F03Rik; KIAA1215; loop-tail; Lp; LPP1; LTAP; ska17; ska; STB1; STBM; STBM1; strabismus; Vang1l2; VANGL2

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UniProt ID: (Human) Q9ULK5, (Rat) P84889, (Mouse) Q91ZD4

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Entrez Gene ID: (Human) 57216, (Rat) 289229, (Mouse) 93840

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功能

protein binding molecular_function

参与通路