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VDAC/Porin Antibody (600-101-HB2) in ICC/IF
Immunofluorescence of Goat Anti-VDAC/Porin Antibody. Cell Line: HeLa Cells. Fixation: 100% MeOH. Permeabilization: 0.3% Triton X-100. Primary Antibody: Anti-VDAC1/Porin at 5µg/mL overnight at 2-8°C. Secondary Antibody: Donkey Anti-Goat IgG DyLight™488 (p/n 605-741-125) at 5µg/mL for 1hr at RT. Nuclear counter stain: DAPI. Location: Mitochondrion, Mitochondrion Outer Membrane, Nucleus. A). DAPI. B). V... View More
产品信息
600-101-HB2
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
VDAC/Porin Antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to N-terminal portion of Human VDAC1/Porin1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Anti-VDAC/Porin Antibody is directed against human VDAC1/Porin1 protein. A BLAST analysis was used to suggest that this antibody would react with VDAC1/Porin1 including mouse, rat, bovine, pig, and rabbit sources based on 100% homology for the immunogen sequence. Such broad reactivity makes this antibody useful as an excellent loading control.
靶标信息
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hVDAC1; MGC111064; Mitochondrial Porin; mVDAC1; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN-31-HL; rVDAC1; VD; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
基因别名: AL033343; PORIN; VDAC; VDAC-1; VDAC1; Vdac5
UniProt ID: (Human) P21796, (Mouse) Q60932, (Rat) Q9Z2L0
Entrez Gene ID: (Human) 7416, (Mouse) 22333, (Rat) 83529
behavioral fear response
anion transport
mitochondrial calcium ion transport
apoptotic process
neuron-neuron synaptic transmission
learning
viral process
macroautophagy
epithelial cell differentiation
anion transmembrane transport
regulation of mitophagy
regulation of anion transmembrane transport
negative regulation of reactive oxygen species metabolic process
transport
ion transport
chemical synaptic transmission
regulation of anion transport
transmembrane transport
ion transmembrane transport
regulation of ion transmembrane transport
