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VE-cadherin Antibody (PA5-120158) in IHC (P)
Immunohistochemistry analysis of VE-cadherin in paraffin-embedded human colon carcinoma. Samples were incubated with VE-cadherin Polyclonal antibody (Product # PA5-120158) using a dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-120158
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 621-784 of human VE Cadherin (NP_0017862)
偶联物
形式
Liquid
浓度
1.19 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2913730
产品详细信息
Positive test controls include: HUVEC, Mouse lung, Mouse brain. The target is usually found in the following locations: Cell junction, Cell membrane, Single-pass type I membrane protein.
Immunogen sequence: RRRLRKQARA HGKSVPEIHE QLVTYDEEGG GEMDTTSYDV SVLNSVRRGG AKPPRPALDA RPSLYAQVQK PPRHAPGAHG GPGEMAAMIE VKKDEADHDG DGPPYDTLHI YGYEGSESIA ESLSSLGTDS SDSDVDYDFL NDWGPRFKML AELYGSDPRE ELLY
靶标信息
VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 7B4 antigen; 7B4/cadherin-5; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; endothelial-specific cadherin; Vascular endothelial cadherin; VE-cadherin
基因别名: 7B4; AA408225; CD144; CDH5; VE-Cad; Vec; VEcad; VECD
UniProt ID: (Human) P33151, (Mouse) P55284
Entrez Gene ID: (Human) 1003, (Mouse) 12562
blood vessel maturation
cell-cell junction assembly
homophilic cell adhesion via plasma membrane adhesion molecules
transforming growth factor beta receptor signaling pathway
negative regulation of cell proliferation
single organismal cell-cell adhesion
adherens junction organization
positive regulation of establishment of endothelial barrier
regulation of establishment of cell polarity
cell adhesion
