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The target sequence has 100% sequence homology with mouse and rat.
Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLT; FLT-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; soluble VEGFR 1; soluble VEGFR2; sVEGFR 1; tyrosine kinase growth factor receptor; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular endothelial growth factor receptor 2; Vascular permeability factor receptor; VEGF R1; VEGFR 1; VEGFR-1; VEGFR-2
基因别名: CD309; FLK1; FLT; FLT-1; FLT1; FRT; KDR; VEGFR; VEGFR-1; VEGFR1; VEGFR2
UniProt ID: (Human) P17948, (Human) P35968
Entrez Gene ID: (Human) 2321, (Human) 3791
分子生物学功能: transmembrane signal receptor