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产品信息
PA5-147023
产品规格
种属反应
Human
已发表种属
Fungi
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human VKORC1
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
0
产品详细信息
Immunogen sequence: ARDRDYRALC DVGTAISCSR VFSSRW
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
靶标信息
Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: IMAGE3455200; phylloquinone epoxide reductase; vitamin K dependent clotting factors deficiency 2; Vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex, subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive)
基因别名: EDTP308; MST134; MST576; MSTP134; MSTP576; UNQ308/PRO351; VKCFD2; VKOR; VKORC1
UniProt ID: (Human) Q9BQB6
Entrez Gene ID: (Human) 79001
