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产品信息
PA5-30528
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 211 and 437 of Human VPS4A
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 1% BSA, 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2548002
产品详细信息
Recommended positive controls: A549, HepG2, HCT116.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (83%), Xenopus laevis (87%), Pig (98%), Rhesus Monkey (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hVPS4; Protein SKD2; SKD1-homolog; vacuolar protein sorting factor 4A; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4-1; VPS4A
基因别名: SKD1; SKD1A; SKD2; VPS4; VPS4-1; VPS4A
UniProt ID: (Human) Q9UN37
Entrez Gene ID: (Human) 27183
cell separation after cytokinesis
membrane budding
autophagy
nucleus organization
vacuole organization
mitotic metaphase plate congression
abscission
protein transport
vesicle-mediated transport
endosomal transport
viral life cycle
viral release from host cell
cytoplasmic microtubule organization
intracellular cholesterol transport
negative regulation of cytokinesis
regulation of protein localization
endosomal vesicle fusion
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
cell division
late endosomal microautophagy
vesicle uncoating
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
positive regulation of viral release from host cell
regulation of protein localization to plasma membrane
positive regulation of exosomal secretion
positive regulation of viral budding via host ESCRT complex
positive regulation of viral life cycle
ESCRT complex disassembly
ESCRT III complex disassembly
