Product References
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment.
Cell reports
Papadas A,Deb G,Cicala A,Officer A,Hope C,Pagenkopf A,Flietner E,Morrow ZT,Emmerich P,Wiesner J,Arauz G,Bansal V,Esbona K,Capitini CM,Matkowskyj KA,Deming DA,Politi K,Abrams SI,Harismendy O,Asimakopoulos F
PA1-1748A was used in Western Blotting to conclude that peritumoral stroma mimicking embryonic provisional matrix remodeling regulates cDC1 abundance and activity to elicit T cell-inflamed tumor microenvironments.
Tue Aug 16 00:00:00 EDT 2022
Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment.
Cell reports
Papadas A,Deb G,Cicala A,Officer A,Hope C,Pagenkopf A,Flietner E,Morrow ZT,Emmerich P,Wiesner J,Arauz G,Bansal V,Esbona K,Capitini CM,Matkowskyj KA,Deming DA,Politi K,Abrams SI,Harismendy O,Asimakopoulos F
PA1-1748A was used in Western Blotting to conclude that peritumoral stroma mimicking embryonic provisional matrix remodeling regulates cDC1 abundance and activity to elicit T cell-inflamed tumor microenvironments.
Tue Aug 16 00:00:00 EDT 2022
Isolation and Purification of Versican and Analysis of Versican Proteolysis.
Methods in molecular biology (Clifton, N.J.)
Foulcer SJ,Day AJ,Apte SS
PA1-1748A was used in Immunohistochemistry, Western Blot to use methodologies for purification and analysis of recombinant versican and an N-terminal versican fragment named versikineo facilitate further progress on the biology of versican and its proteolysis..
Tue Jan 11 00:00:00 EST 2022
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide.
Scientific reports
Santamaria S,Cuffaro D,Nuti E,Ciccone L,Tuccinardi T,Liva F,D'Andrea F,de Groot R,Rossello A,Ahnström J
PA1-1748A was used in In vitro Assay to design a new class of sugar-based arylsulfonamides.
Wed Jan 13 00:00:00 EST 2021
Exosite inhibition of ADAMTS-5 by a glycoconjugated arylsulfonamide.
Scientific reports
Santamaria S,Cuffaro D,Nuti E,Ciccone L,Tuccinardi T,Liva F,D'Andrea F,de Groot R,Rossello A,Ahnström J
PA1-1748A was used in In vitro Assay to design a new class of sugar-based arylsulfonamides.
Wed Jan 13 00:00:00 EST 2021
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
The Journal of experimental medicine
Hong CC,Tang AT,Detter MR,Choi JP,Wang R,Yang X,Guerrero AA,Wittig CF,Hobson N,Girard R,Lightle R,Moore T,Shenkar R,Polster SP,Goddard LM,Ren AA,Leu NA,Sterling S,Yang J,Li L,Chen M,Mericko-Ishizuka P,Dow LE,Watanabe H,Schwaninger M,Min W,Marchuk DA,Zheng X,Awad IA,Kahn ML
PA1-1748A was used in Immunohistochemistry to identify endothelial secretion of ADAMTS5 and cleavage of versican as downstream mechanisms of CCM pathogenesis and provide a basis for the participation of wild-type endothelial cells in lesion formation.
Mon Oct 05 00:00:00 EDT 2020
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
The Journal of experimental medicine
Hong CC,Tang AT,Detter MR,Choi JP,Wang R,Yang X,Guerrero AA,Wittig CF,Hobson N,Girard R,Lightle R,Moore T,Shenkar R,Polster SP,Goddard LM,Ren AA,Leu NA,Sterling S,Yang J,Li L,Chen M,Mericko-Ishizuka P,Dow LE,Watanabe H,Schwaninger M,Min W,Marchuk DA,Zheng X,Awad IA,Kahn ML
PA1-1748A was used in Immunohistochemistry to identify endothelial secretion of ADAMTS5 and cleavage of versican as downstream mechanisms of CCM pathogenesis and provide a basis for the participation of wild-type endothelial cells in lesion formation.
Mon Oct 05 00:00:00 EDT 2020
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
The Journal of experimental medicine
Hong CC,Tang AT,Detter MR,Choi JP,Wang R,Yang X,Guerrero AA,Wittig CF,Hobson N,Girard R,Lightle R,Moore T,Shenkar R,Polster SP,Goddard LM,Ren AA,Leu NA,Sterling S,Yang J,Li L,Chen M,Mericko-Ishizuka P,Dow LE,Watanabe H,Schwaninger M,Min W,Marchuk DA,Zheng X,Awad IA,Kahn ML
PA1-1748A was used in Immunohistochemistry to identify endothelial secretion of ADAMTS5 and cleavage of versican as downstream mechanisms of CCM pathogenesis and provide a basis for the participation of wild-type endothelial cells in lesion formation.
Mon Oct 05 00:00:00 EDT 2020
ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer.
Biomolecules
Binder MJ,McCoombe S,Williams ED,McCulloch DR,Ward AC
PA1-1748A was used in Immunohistochemistry-immunofluorescence to analyze the expression of ADAMTS-15 in human prostate cancer, and investigate the effects of enforced expression in prostate cancer cell lines.
Tue Apr 28 00:00:00 EDT 2020
ADAMTS-15 Has a Tumor Suppressor Role in Prostate Cancer.
Biomolecules
Binder MJ,McCoombe S,Williams ED,McCulloch DR,Ward AC
PA1-1748A was used in Immunohistochemistry-immunofluorescence to analyze the expression of ADAMTS-15 in human prostate cancer, and investigate the effects of enforced expression in prostate cancer cell lines.
Tue Apr 28 00:00:00 EDT 2020
Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.
Biomolecules
Addinsall AB,Forgan LG,McRae NL,Kelly RW,McDonald PL,McNeill B,McCulloch DR,Stupka N
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Sat Mar 07 00:00:00 EST 2020
Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.
Biomolecules
Addinsall AB,Forgan LG,McRae NL,Kelly RW,McDonald PL,McNeill B,McCulloch DR,Stupka N
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Sat Mar 07 00:00:00 EST 2020
Treatment of Dystrophic mdx Mice with an ADAMTS-5 Specific Monoclonal Antibody Increases the Ex Vivo Strength of Isolated Fast Twitch Hindlimb Muscles.
Biomolecules
Addinsall AB,Forgan LG,McRae NL,Kelly RW,McDonald PL,McNeill B,McCulloch DR,Stupka N
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Sat Mar 07 00:00:00 EST 2020
Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
Cell reports
Han CY,Kang I,Harten IA,Gebe JA,Chan CK,Omer M,Alonge KM,den Hartigh LJ,Gomes Kjerulf D,Goodspeed L,Subramanian S,Wang S,Kim F,Birk DE,Wight TN,Chait A
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Tue Jun 30 00:00:00 EDT 2020
Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles.
Scientific reports
McRae NL,Addinsall AB,Howlett KF,McNeill B,McCulloch DR,Stupka N
PA1-1748A was used in Immunohistochemistry to study the role of Versican in the pathogenesis of muscular dystrophy.
Mon Jul 06 00:00:00 EDT 2020
Genetic reduction of the extracellular matrix protein versican attenuates inflammatory cell infiltration and improves contractile function in dystrophic mdx diaphragm muscles.
Scientific reports
McRae NL,Addinsall AB,Howlett KF,McNeill B,McCulloch DR,Stupka N
PA1-1748A was used in Immunohistochemistry to study the role of Versican in the pathogenesis of muscular dystrophy.
Mon Jul 06 00:00:00 EDT 2020
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.
eLife
Nandadasa S,Szafron JM,Pathak V,Murtada SI,Kraft CM,O'Donnell A,Norvik C,Hughes C,Caterson B,Domowicz MS,Schwartz NB,Tran-Lundmark K,Veigl M,Sedwick D,Philipson EH,Humphrey JD,Apte SS
PA1-1748A was used in Immunocytochemistry to analyse of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting vascular responses.
Thu Sep 10 00:00:00 EDT 2020
Versican proteolysis predicts immune effector infiltration and post-transplant survival in myeloma.
Leukemia & lymphoma
Dhakal B,Pagenkopf A,Mushtaq MU,Cunningham AM,Flietner E,Morrow Z,Papadas A,Hope C,Leith C,Hematti P,Hari P,Callander NS,Asimakopoulos F
PA1-1748A was used in Immunohistochemistry to open the door to future mechanistic investigations to better understand the role of tissue resident eosinophils in different context.
Tue Oct 01 00:00:00 EDT 2019
Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.
JCI insight
Sandireddy R,Cibi DM,Gupta P,Singh A,Tee N,Uemura A,Epstein JA,Singh MK
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Immunohistochemistry
Thu Aug 22 00:00:00 EDT 2019
Semaphorin 3E/PlexinD1 signaling is required for cardiac ventricular compaction.
JCI insight
Sandireddy R,Cibi DM,Gupta P,Singh A,Tee N,Uemura A,Epstein JA,Singh MK
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Immunohistochemistry
Thu Aug 22 00:00:00 EDT 2019
ADAMTS5 deficiency in mice does not affect cardiac function.
Cell biology international
Hemmeryckx B,Carai P,Roger Lijnen H
PA1-1748A was used in Western Blotting to investigate the potential role of ADAMTS5 in cardiac function using ADAMTS5-deficient (Adamts5-/- ) mice and their wild-type (Adamts5+/+ ) counterparts exposed to a standard-fat or a high-fat diet (HFD).
Sat Jun 01 00:00:00 EDT 2019
Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.
The Journal of clinical investigation
Lin W,Li D,Cheng L,Li L,Liu F,Hand NJ,Epstein JA,Rader DJ
PA1-1748A was used in Western Blotting to identify a gene underlying ventricular trabeculation and compaction development, and a pathway regulating extracellular matrix during myocardial morphogenesis.
Thu Feb 01 00:00:00 EST 2018
Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.
The Journal of clinical investigation
Lin W,Li D,Cheng L,Li L,Liu F,Hand NJ,Epstein JA,Rader DJ
PA1-1748A was used in Western Blotting to identify a gene underlying ventricular trabeculation and compaction development, and a pathway regulating extracellular matrix during myocardial morphogenesis.
Thu Feb 01 00:00:00 EST 2018
Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.
The Journal of clinical endocrinology and metabolism
Gueye NA,Mead TJ,Koch CD,Biscotti CV,Falcone T,Apte SS
PA1-1748A was used in Western Blotting to investigate ADAMTS protease-mediated versican cleavage in myometrium and leiomyoma, and the effect of versican knockdown in leiomyoma cells.
Mon May 01 00:00:00 EDT 2017
Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.
The Journal of clinical endocrinology and metabolism
Gueye NA,Mead TJ,Koch CD,Biscotti CV,Falcone T,Apte SS
PA1-1748A was used in Western Blotting to investigate ADAMTS protease-mediated versican cleavage in myometrium and leiomyoma, and the effect of versican knockdown in leiomyoma cells.
Mon May 01 00:00:00 EDT 2017
Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Hope C,Emmerich PB,Papadas A,Pagenkopf A,Matkowskyj KA,Van De Hey DR,Payne SN,Clipson L,Callander NS,Hematti P,Miyamoto S,Johnson MG,Deming DA,Asimakopoulos F
PA1-1748A was used in Immunohistochemistry to study the cellular responses to versican in colorectal cancer, and assess its potential as a predictive and/or prognostic immune biomarker.
Fri Sep 01 00:00:00 EDT 2017
Versican-Derived Matrikines Regulate Batf3-Dendritic Cell Differentiation and Promote T Cell Infiltration in Colorectal Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Hope C,Emmerich PB,Papadas A,Pagenkopf A,Matkowskyj KA,Van De Hey DR,Payne SN,Clipson L,Callander NS,Hematti P,Miyamoto S,Johnson MG,Deming DA,Asimakopoulos F
PA1-1748A was used in Immunohistochemistry to study the cellular responses to versican in colorectal cancer, and assess its potential as a predictive and/or prognostic immune biomarker.
Fri Sep 01 00:00:00 EDT 2017
Glucocorticoids Improve Myogenic Differentiation In Vitro by Suppressing the Synthesis of Versican, a Transitional Matrix Protein Overexpressed in Dystrophic Skeletal Muscles.
International journal of molecular sciences
McRae N,Forgan L,McNeill B,Addinsall A,McCulloch D,Van der Poel C,Stupka N
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Wed Dec 06 00:00:00 EST 2017
Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Nature
Zhou Z,Tang AT,Wong WY,Bamezai S,Goddard LM,Shenkar R,Zhou S,Yang J,Wright AC,Foley M,Arthur JS,Whitehead KJ,Awad IA,Li DY,Zheng X,Kahn ML
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Immunofluorescence
Thu Apr 07 00:00:00 EDT 2016
Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome.
Scientific reports
Dubail J,Vasudevan D,Wang LW,Earp SE,Jenkins MW,Haltiwanger RS,Apte SS
PA1-1748A was used in immunohistochemistry - paraffin section describe a role for ADAMTS9 in ocular morphogenesis
Fri Sep 30 00:00:00 EDT 2016
Elevated expression of long intergenic non-coding RNA HOTAIR in a basal-like variant of MCF-7 breast cancer cells.
Molecular carcinogenesis
Zhuang Y,Nguyen HT,Burow ME,Zhuo Y,El-Dahr SS,Yao X,Cao S,Flemington EK,Nephew KP,Fang F,Collins-Burow B,Rhodes LV,Yu Q,Jayawickramarajah J,Shan B
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Tue Dec 01 00:00:00 EST 2015
Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Snyder JM,Washington IM,Birkland T,Chang MY,Frevert CW
PA1-1748A was used in immunohistochemistry to determine versican expression in the murine lung and central nervous system
Tue Dec 01 00:00:00 EST 2015
Correlation of Versican Expression, Accumulation, and Degradation during Embryonic Development by Quantitative Immunohistochemistry.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Snyder JM,Washington IM,Birkland T,Chang MY,Frevert CW
PA1-1748A was used in immunohistochemistry to determine versican expression in the murine lung and central nervous system
Tue Dec 01 00:00:00 EST 2015
Versican localizes to the nucleus in proliferating mesenchymal cells.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Carthy JM,Abraham T,Meredith AJ,Boroomand S,McManus BM
PA1-1748A was used in immunocytochemistry and western blot to discuss intracellular functions of versican
Mon Aug 22 00:00:00 EDT 2016
Versican localizes to the nucleus in proliferating mesenchymal cells.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology
Carthy JM,Abraham T,Meredith AJ,Boroomand S,McManus BM
PA1-1748A was used in immunocytochemistry and western blot to discuss intracellular functions of versican
Mon Aug 22 00:00:00 EDT 2016
ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.
Cell reports
Nandadasa S,Nelson CM,Apte SS
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Immunofluorescence
Tue Jun 16 00:00:00 EDT 2015
Galnt1 is required for normal heart valve development and cardiac function.
PloS one
Tian E,Stevens SR,Guan Y,Springer DA,Anderson SA,Starost MF,Patel V,Ten Hagen KG,Tabak LA
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Immunofluorescence
Tue May 03 00:00:00 EDT 2016
Isolation and purification of versican and analysis of versican proteolysis.
Methods in molecular biology (Clifton, N.J.)
Foulcer SJ,Day AJ,Apte SS
PA1-1748A was used in Immunohistochemistry to describe the isolation and detection of intact and cleaved versican in tissues.
Wed Jun 17 00:00:00 EDT 2015
Differential effects of caveolin-1 and -2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells.
Investigative ophthalmology & visual science
Aga M,Bradley JM,Wanchu R,Yang YF,Acott TS,Keller KE
PA1-1748A was used in immunohistochemistry and western blot to investigate the role of caveolin-1 and -2 in aqueous outflow and extracellular matrix turnover in trabecular meshwork cells
Thu Aug 07 00:00:00 EDT 2014
Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.
The Journal of biological chemistry
Dancevic CM,Fraser FW,Smith AD,Stupka N,Ward AC,McCulloch DR
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Fri Dec 27 00:00:00 EST 2013
Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15: a novel versican-cleaving proteoglycanase.
The Journal of biological chemistry
Dancevic CM,Fraser FW,Smith AD,Stupka N,Ward AC,McCulloch DR
Published figure using Versican V0, V1 Neo polyclonal antibody (Product # PA1-1748A) in Western Blot
Fri Dec 27 00:00:00 EST 2013
Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis.
Nature communications
Li S,Thangapazham RL,Wang JA,Rajesh S,Kao TC,Sperling L,Moss J,Darling TN
PA1-1748A was used in immunohistochemistry to study the role of tuberous sclerosis complex in hair follicle formation and tissue regeneration
Mon Aug 01 00:00:00 EDT 2011
Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis.
The Journal of biological chemistry
Hattori N,Carrino DA,Lauer ME,Vasanji A,Wylie JD,Nelson CM,Apte SS
PA1-1748A was used in western blot to study regulation of the composition and volume of glycosaminoglycan-rich pericellular matrix in fibroblasts
Fri Sep 30 00:00:00 EDT 2011
Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.
Matrix biology : journal of the International Society for Matrix Biology
Kern CB,Wessels A,McGarity J,Dixon LJ,Alston E,Argraves WS,Geeting D,Nelson CM,Menick DR,Apte SS
PA1-1748A was used in immunohistochemistry to study the roel of versican-degrading protease ADAMTS9 in cardiovascular development and adult homeostasis
Sat May 01 00:00:00 EDT 2010
Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion.
American journal of respiratory cell and molecular biology
Potter-Perigo S,Johnson PY,Evanko SP,Chan CK,Braun KR,Wilkinson TS,Altman LC,Wight TN
PA1-1748A was used in western blot to investigate the effect of polyinosine-polycytidylic acid on versican accumulation in the extracellular matrix of human lung fibroblast cultures
Thu Jul 01 00:00:00 EDT 2010
Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Shukla S,Nair R,Rolle MW,Braun KR,Chan CK,Johnson PY,Wight TN,McDevitt TC
PA1-1748A was used in western blot to investigate hyaluronan and versican during embryonic stem differentiation
Thu Apr 01 00:00:00 EDT 2010
Proteolytic cleavage of versican during limb joint development.
Anatomical record (Hoboken, N.J. : 2007)
Capehart AA
PA1-1748A was used in immunohistochemistry to study the proteolytic processing of versican during limb joint development
Mon Feb 01 00:00:00 EST 2010
Versican proteolysis mediates myocardial regression during outflow tract development.
Developmental dynamics : an official publication of the American Association of Anatomists
Kern CB,Norris RA,Thompson RP,Argraves WS,Fairey SE,Reyes L,Hoffman S,Markwald RR,Mjaatvedt CH
PA1-1748A was used in immunohistochemistry to study the role of versican proteolysis in distal myocardium loss during outflow tract remodeling
Thu Mar 01 00:00:00 EST 2007
Versican proteolysis mediates myocardial regression during outflow tract development.
Developmental dynamics : an official publication of the American Association of Anatomists
Kern CB,Norris RA,Thompson RP,Argraves WS,Fairey SE,Reyes L,Hoffman S,Markwald RR,Mjaatvedt CH
PA1-1748A was used in immunohistochemistry to study the role of versican proteolysis in distal myocardium loss during outflow tract remodeling
Thu Mar 01 00:00:00 EST 2007
