Invitrogen

Villin Polyclonal Antibody

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抗体检测数据 (1)

Villin Antibody in Western Blot (WB)

Villin Antibody in Western Blot (WB)

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Villin Antibody (PA5-116115) in WB

Western blot analysis of Villin in MCF7 cells (left lane: treated with blocking peptide). Samples were incubated with polyclonal antibody (Product # PA5-116115).

Villin Antibody in Western Blot (WB)

Product Image Gallery

Villin Antibody in Western Blot (WB) — Western blot analysis of Villin in MCF7 cells (left lane: treated with blocking peptide). Samples were incubated with polyclonal antibody (Product # PA5-116115).

产品信息

PA5-116115

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:200

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human VIL1(Accession P09327), corresponding to amino acid residues D575-S625.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2900749

产品详细信息

Antibody detects endogenous levels of total Villin1.

靶标信息

Villin is part of cytoskeleton associated with the microvillar actin core bundle of gastrointestinal and renal brush border. It can interact with actin in a Ca2+ and phosphoinositide-regulated manner. Villin is a very specific marker for adenocarcinomas of the gastrointestinal tract and the pancreas. It is also expressed in some Merkel cell tumor and adenocarcinoma of the lung, prostate, ovarian and kidney.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: OTTHUMP00000207159; Villin-1

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基因别名: D2S1471; VIL; VIL1

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UniProt ID: (Human) P09327, (Mouse) Q62468

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Entrez Gene ID: (Human) 7429, (Mouse) 22349, (Rat) 316521

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calcium ion binding protein binding phosphatidylinositol-4,5-bisphosphate binding lysophosphatidic acid binding identical protein binding protein homodimerization activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process actin filament binding actin binding metal ion binding molecular_function non-motor actin binding protein

参与通路

intestinal D-glucose absorption protein complex assembly apoptotic process epidermal growth factor receptor signaling pathway regulation of cell shape response to bacterium positive regulation of epithelial cell migration actin filament polymerization actin filament depolymerization positive regulation of cell migration positive regulation of actin filament depolymerization epithelial cell differentiation positive regulation of actin filament bundle assembly regulation of microvillus length cellular response to hepatocyte growth factor stimulus positive regulation of multicellular organism growth negative regulation of cysteine-type endopeptidase activity involved in apoptotic process actin nucleation actin filament severing barbed-end actin filament capping regulation of actin nucleation actin filament capping cytoplasmic actin-based contraction involved in cell motility regulation of wound healing cellular response to epidermal growth factor stimulus positive regulation of establishment of protein localization to plasma membrane terminal web assembly regulation of lamellipodium morphogenesis positive regulation of lamellipodium morphogenesis cytoskeleton organization microvillus assembly biological_process