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Invitrogen
Vimentin Monoclonal Antibody (V9), Alexa Fluor™ 647
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
图: 1 / 9
Vimentin Antibody (MA5-11883-A647) in IHC (P)
Immunohistochemical analysis of Vimentin was performed using formalin-fixed paraffin-embedded human breast infiltrating ductal carcinoma tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - High pH (10X) (Product # 00-4956-58) diluted to 1X solution in water in a decloaking chamber at 110 d... View More
产品信息
MA5-11883-A647
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Chicken,
Horse,
Cat,
Gerbil,
Hamster,
Human,
Mouse,
Non-human primate,
Pig,
Rabbit,
Rat
已发表种属
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
V9
抗原
Purified vimentin from pig eye lens
偶联物
激发/发射光谱
650/671 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2662891
产品详细信息
The MA511883A647 immunogen is purified vimentin from pig eye lens.
靶标信息
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: epididymis luminal protein 113; FLJ36605; intermediate filament protein; RP11-124N14.1; VIME; Vimentin; vimentin C-terminus
基因别名: CTRCT30; HEL113; VIM
UniProt ID: (Pig) P02543, (Bovine) P48616, (Human) P08670, (Dog) A0A8C0N8E3, (Mouse) P20152, (Rat) P31000
double-stranded RNA binding
structural constituent of cytoskeleton
structural constituent of eye lens
protein domain specific binding
identical protein binding
scaffold protein binding
keratin filament binding
protein binding
glycoprotein binding
protein C-terminus binding
structural molecule activity
kinase binding
protein kinase binding
protein phosphatase 2A binding
negative regulation of neuron projection development
astrocyte development
positive regulation of collagen biosynthetic process
regulation of mRNA stability
intermediate filament organization
positive regulation of translation
Bergmann glial cell differentiation
SMAD protein signal transduction
lens fiber cell development
cellular response to lipopolysaccharide
cellular response to muramyl dipeptide
cellular response to interferon-gamma
positive regulation of gene expression
intermediate filament-based process
regulation of axonogenesis
positive regulation of glial cell proliferation
regulation of Schwann cell migration
in utero embryonic development
positive regulation of superoxide anion generation
movement of cell or subcellular component
viral process
muscle filament sliding
aging
response to radiation
response to zinc ion
response to selenium ion
response to estradiol
response to vitamin D
skeletal muscle tissue regeneration
cellular response to fibroblast growth factor stimulus
fat cell differentiation
decidualization
