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A suggested positive control is human testis tissue lysate.
PA5-34536 can be used with blocking peptide PEP-1579.
The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: WW domain-containing adapter protein with coiled-coil; WW domain-containing adaptor with coiled-coil; WW domain-containing protein 4
基因别名: 1110067P07Rik; A230035H12Rik; AI256735; AI256776; BM-016; DESSH; KIAA1844; PRO1741; RGD1562407; WAC; Wwp4
UniProt ID: (Human) Q9BTA9, (Mouse) Q924H7
Entrez Gene ID: (Human) 51322, (Rat) 307029, (Mouse) 225131
分子生物学功能:
scaffold/adaptor protein