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产品信息
BS-10578R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human WASF3, amino acids 21-120.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C
运输条件
Wet ice
靶标信息
WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating actin reorganization downstream of the Rho family of small GTPases. The two protein homologs WAVE1 and WAVE2 specifically regulate membrane ruffling by inducing the formation of actin filament clusters in response to GTP binding and activating Rac. The WAVE proteins mediate this actin polymerization by cooperating with the Arp2/3 complex, a nucleation core, and thereby promoting the formation of actin filaments. WAVE1, which is also designated SCAR (for suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
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生物信息学
蛋白别名: Actin-binding protein WASF3; Protein WAVE-3; Verprolin homology domain-containing protein 3; WAS protein family, member 3; WASP family protein member 3; WASP family Verprolin-homologous protein 3; Wiskott-Aldrich syndrome protein family member 3
基因别名: Brush-1; KIAA0900; SCAR3; WASF3; WAVE3
UniProt ID: (Human) Q9UPY6, (Mouse) Q8VHI6
Entrez Gene ID: (Human) 10810, (Mouse) 245880, (Rat) 682937
