Invitrogen

WDR35 Polyclonal Antibody

产品信息

PA5-60629

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:50

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human WDR35. Recombinant protein control fragment (Product #RP-99642).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2649570

产品详细信息

Immunogen sequence: SLPNVGLIQK YSLNCRAYQL SLNCNSSRLA IIDISGVLTF FDLDARVTDS TGQQVVGELL KLERRDVWDM KWAKDNPDLF AMMEKTRMYV FRNLDPEEPI QTSGY

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

靶标信息

WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。