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Immunogen sequence: CSDDRTVRIW RQYLPGNEQG VACSGSDPSW KCICTLSGFH SRTIYDIAWC QLTGALATAC GDDAIRVFQE DPNSDPQQPT FSLTAHLHQA HSQDVNCVAW NPKEPGLLAS CSDDGEVAFW KYQR
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 92%.
WDR39 is a member of the WD40 family of proteins. WDR39 specifically interacts with WT1 both in vitro and in vivo. This interaction results in a decrease in transcriptional activation mediated by WT1. WDR39 does not inhibit binding of WT1 to its consensus nucleotide sequence and does not affect the repression activity of WT1. Thus, WDR39 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CIAO1; cytosolic iron-sulfur protein assembly 1 homolog; Probable cytosolic iron-sulfur protein assembly protein CIAO1; WD repeat domain 39; WD repeat-containing protein 39; WD40 protein Ciao1
基因别名: CIA1; CIAO1; WDR39
UniProt ID: (Human) O76071
Entrez Gene ID: (Human) 9391