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Immunogen sequence: ESCEEKNQL ILTASADRTV IVWDGDTTRQ VQRISCFQST VKCLTVLQRL DVWLSGGNDL CVWNRKLDLL CKTSHLSDTG ISALVEIPKN CVVAAVGKEL IIFRLVAPTE GSLEWDILEV KRLLDHQDNI LSLINVNDLS FVTGSHVGEL IIWDALDWTM QAYERNFWDP SPQLDTQQEI KLCQKSNDIS IHHFTCDEEN VFAAVGRGLY VYSLQMKRVI ACQKTAHDSN VLHVARLPNR QLISCSEDGS VRIWELREKQ QLAAEPVPTG FFNMWGFGRV SKQASQPVKK QQENATSCSL ELIGDLIGHS SSVEMFLYFE DHGLVTCSAD HLIILWKNGE RESGLRSLRL FQKLEENGDL YLAV (97-459 aa encoded by BC040241)
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: WD repeat-containing protein 41
基因别名: MSTP048; WDR41
UniProt ID: (Human) Q9HAD4
Entrez Gene ID: (Human) 55255