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产品信息
WIT-101AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Fruit fly
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 700-750 on WIT Wishful Thinking D. melanogaster protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Wishful thinking (wit) gene, the Drosophila homolog of the vertebrate BMP type II receptor. Mutations in wit result in pharate lethality that can be rescued by expression of a wit transgene in motor neurons but not in muscles. Mutant larvae exhibit small synapses, severe defects in evoked junctional potentials, a lower frequency of spontaneous vesicle release, and an alteration in the ultrastructure of synaptic active zones.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: bone morphogenetic protein; CG10776; CG10776-PA; CG10776-PB; GH13548p; Receptor protein serine/threonine kinase; Serine/threonine kinase-D; wit; wit-PA; wit-PB
基因别名: 1262/15; ALK3/BMPRII; BMP; CG10776; Dmel\CG10776; Dmel_CG10776; l(3)64Aa; l(3)S126215; l(3)SH12; SE20; STK-D; WIT; Wit-C; wiw
Entrez Gene ID: (Fruit fly) 44096
protein phosphorylation
neuromuscular synaptic transmission
ventral cord development
neuromuscular junction development
BMP signaling pathway
activin receptor signaling pathway
positive regulation of synaptic growth at neuromuscular junction
dendrite morphogenesis
synaptic growth at neuromuscular junction
SMAD protein signal transduction
cellular response to growth factor stimulus
