Invitrogen

WNT7A Polyclonal Antibody

图: 1 / 1

WNT7A Antibody (PA5-78227) in WB

WNT7A Polyclonal Antibody detects WNT7A protein by Western blot analysis. A. 30 µg 293T whole cell lysate/extract. B. 30 whole cell lysate/extract of V5-human Wnt7A-transfected 293T cells.10 % SDS-PAGE. WNT7A Polyclonal Antibody (Product # PA5-78227) dilution: 1:5,000.

Product Image Gallery

产品信息

PA5-78227

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:10,000

产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human WNT7A. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2736801

产品详细信息

Positive Control: V5-human Wnt7A-transfected 293T cells

Predicted Reactivity: Mouse (100%), Rat (100%), Chicken (94%), Rhesus Monkey (100%), Bovine (97%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of ß-catenin degradation. Intracellular accumulation of ß-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/ß-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family, member 7A

查看更多收起

基因别名: WNT7A

查看更多收起

UniProt ID: (Human) O00755

查看更多收起

Entrez Gene ID: (Human) 7476, (Rat) 114850

查看更多收起

功能

receptor binding frizzled binding cytokine activity protein binding receptor agonist activity intercellular signal molecule

参与通路