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产品信息
PA5-20038
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to amino acids at the C-terminus of human XAF-1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154647
产品详细信息
In Western blot applications, this antibody detects a band at ~32kDa. A suggested positive control is human spleen tissue lysate.
PA5-20038 can be used with blocking peptide PEP-0157.
靶标信息
The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BIRC4 binding protein; BIRC4-binding protein; F-box protein 39; novel TRAF-type zinc finger protein; XIAP-associated factor 1
基因别名: BIRC4BP; Fbox39; HSXIAPAF1; XAF1; XIAPAF1
UniProt ID: (Human) Q6GPH4, (Mouse) Q5NBU8
Entrez Gene ID: (Human) 54739, (Mouse) 327959
