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XBP1 Antibody (H00007494-B01P) in WB
Western Blot analysis of XBP1 expression in transfected 293T cell line (H00007494-T01) by XBP1 MaxPab polyclonal antibody.
Lane 1: XBP1 transfected lysate(28.71 KDa).
Lane 2: Non-transfected lysate.
Lane 1: XBP1 transfected lysate(28.71 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00007494-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
XBP1 (NP_005071.2, 1 a.a. approximately 261 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MVVVAAAPNP ADGTPKVLLL SGQPASAAGA PAGQALPLMV PAQRGASPEA ASGGLPQARK RQRLTHLSPE EKALRRKLKN RVAAQTARDR KKARMSELEQ QVVDLEEENQ KLLLENQLLR EKTHGLVVEN QELRQRLGMD ALVAEEEAEA KGNEVRPVAG SAESAALRLR APLQQVQAQL SPLQNISPWI LAVLTLQIQS LISCWAFWTT WTQSCSSNAL PQSLPAWRSS QRSTQKDPVP YQPPFLCQWG RHQPSWKPLM N
靶标信息
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: OTTHUMP00000028682; Tax-responsive element-binding protein 5; TREB-5; X-box-binding protein 1; XBP-1
基因别名: TREB-5; TREB5; XBP-1; XBP1; XBP2
UniProt ID: (Human) P17861
Entrez Gene ID: (Human) 7494
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter binding
RNA polymerase II transcription factor binding
enhancer sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
phosphatidylinositol 3-kinase regulatory subunit binding
histone deacetylase binding
protein heterodimerization activity
angiogenesis
liver development
endothelial cell proliferation
positive regulation of immunoglobulin production
transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
fatty acid biosynthetic process
autophagy
immune response
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
muscle organ development
regulation of autophagy
negative regulation of myotube differentiation
protein transport
endoplasmic reticulum unfolded protein response
exocrine pancreas development
protein destabilization
cellular response to nutrient
cellular response to insulin stimulus
cellular triglyceride homeostasis
IRE1-mediated unfolded protein response
ATF6-mediated unfolded protein response
cellular response to glucose starvation
cholesterol homeostasis
negative regulation of apoptotic process
positive regulation of MHC class II biosynthetic process
positive regulation of B cell differentiation
positive regulation of T cell differentiation
positive regulation of fat cell differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron development
positive regulation of immunoglobulin secretion
fatty acid homeostasis
sterol homeostasis
adipose tissue development
epithelial cell maturation involved in salivary gland development
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to lipopolysaccharide
cellular response to amino acid stimulus
cellular response to fructose stimulus
cellular response to glucose stimulus
cellular response to interleukin-4
cellular response to peptide hormone stimulus
positive regulation of plasma cell differentiation
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of proteasomal protein catabolic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of lactation
response to insulin-like growth factor stimulus
positive regulation of hepatocyte proliferation
positive regulation of interleukin-6 secretion
