Invitrogen

XDH Polyclonal Antibody

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抗体检测数据 (2)

XDH Antibody in Western Blot (WB)

XDH Antibody in Western Blot (WB)

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XDH Antibody (PA5-88946) in WB

Western blot analysis of XDH in extracts of various cell lines. Samples were incubated with XDH Polyclonal antibody (Product # PA5-88946) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

XDH Antibody in Western Blot (WB)

XDH Antibody in Western Blot (WB)

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XDH Antibody in Western Blot (WB) — Western blot analysis of XDH in extracts of various cell lines. Samples were incubated with XDH Polyclonal antibody (Product # PA5-88946) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

XDH Antibody in Western Blot (WB) — Western blot analysis of XDH in extracts of various cell lines. Samples were incubated with XDH Polyclonal antibody (Product # PA5-88946) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

产品信息

PA5-88946

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 985-1084 of human Xanthine Oxidase (XDH) (NP_0003702)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.63 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2805243

产品详细信息

Positive Samples: Mouse liver; Cellular Location: Cytoplasm, Peroxisome

Immunogen sequence: ETSTNTVPNT SPTAASVSA

靶标信息

XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody

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基因别名: XDH; XDHA; XO; XOR; Xox-1; Xox1

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UniProt ID: (Human) P47989, (Rat) P22985, (Mouse) Q00519

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Entrez Gene ID: (Human) 7498, (Rat) 497811, (Mouse) 22436

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xanthine dehydrogenase activity xanthine oxidase activity iron ion binding electron carrier activity oxidoreductase activity, acting on CH-OH group of donors oxidoreductase activity, acting on the aldehyde or oxo group of donors protein homodimerization activity molybdopterin cofactor binding flavin adenine dinucleotide binding 2 iron, 2 sulfur cluster binding UDP-N-acetylmuramate dehydrogenase activity oxidoreductase activity catalytic activity protein binding molybdenum ion binding metal ion binding iron-sulfur cluster binding oxidoreductase metabolite interconversion enzyme

参与通路

negative regulation of protein phosphorylation negative regulation of endothelial cell proliferation purine nucleotide catabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process lactation xanthine catabolic process negative regulation of gene expression negative regulation of endothelial cell differentiation negative regulation of protein kinase B signaling oxidation-reduction process positive regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of vasculogenesis response to aluminum ion regulation of epithelial cell differentiation bone resorption