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For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.
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蛋白别名: Ku70 binding protein 3; Ku70-binding protein 3; Mitochondrial inner membrane protease ATP23 homolog; XRCC6 binding protein 1; XRCC6-binding protein 1
基因别名: ATP23; KUB3; XRCC6BP1
UniProt ID: (Human) Q9Y6H3
Entrez Gene ID: (Human) 91419
分子生物学功能: metalloprotease