Invitrogen

YAP1 (R331W Mutant) Polyclonal Antibody

YAP1 (R331W Mutant) Antibody in Western Blot (WB)

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YAP1 (R331W Mutant) Antibody (PA5-117450) in WB

Western blot analysis of YAP1 (R331W Mutant) in Non-transfected (–) and transfected (+) 293T whole cell extracts (30 µg). Samples were separated with 10% SDS-PAGE and incubated in YAP1 (R331W Mutant) polyclonal antibody (Product # PA5-117450) using a dilution of 1:5,000, followed by HRP-conjugated anti-rabbit IgG.

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产品信息

PA5-117450

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:5,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human YAP1 (R331W Mutant). The exact sequence is proprietary.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.14 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.025% ProClin 300

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2902080

产品详细信息

Centrifuge briefly prior to opening.

YAP1 is an oncogene and the YAP1 R331W missense mutation from the original family may be associated with lung adenocarcinoma.

靶标信息

YAP (Yes-Associated Protein) is a founding member of the WW domain family of proteins, transcriptional co-activator and oncogene. Its gene is transcriptionally activated in squamous cell carcinoma cells. YAP can act both as a coactivator and corepressor and is the critical downstream regulatory target in the Hippo signaling pathway. The Hippo signaling pathway plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. Also plays key roles in tissue tension, 3D tissue shape, cell proliferation, cell death, and cell migration. Mutations in the IRF5 gene results in coloboma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 65 kDa Yes-associated protein; Protein yorkie homolog; Transcriptional coactivator YAP1; Yes-associated protein 1; yes-associated protein 2; Yes-associated protein YAP65 homolog; yorkie homolog

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基因别名: COB1; YAP; YAP1; YAP2; YAP65; YKI

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UniProt ID: (Human) P46937

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Entrez Gene ID: (Human) 10413

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功能

RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding chromatin binding transcription coactivator activity transcription corepressor activity protein binding protein C-terminus binding transcription regulatory region DNA binding proline-rich region binding transcription cofactor

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