Proteintech

YTHDF1 Polyclonal Antibody

YTHDF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 22

YTHDF1 Antibody (17479-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue slide using (Product # 17479-1-AP) YTHDF1 antibody at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

YTHDF1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

YTHDF1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

产品信息

17479-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看142篇已发表文章 142篇已发表文章

免疫组化 (IHC)

查看26篇已发表文章 26篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:500

免疫细胞化学 (ICC/IF)

1:50-1:500

查看23篇已发表文章 23篇已发表文章

流式细胞分析 (Flow)

查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

查看7篇已发表文章 7篇已发表文章

RNA免疫共沉淀 (RIP)

查看41篇已发表文章 41篇已发表文章

其他PubMed (Misc)

查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Non-human primate

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

YTHDF1 Fusion Protein Ag11509 (210-559 aa encoded by BC050284)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.26 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: VALTGVLSG NGGTNVNMPV SKPTSWAAIA SKPAKPQPKM KTKSGPVMGG GLPPPPIKHN MDIGTWDNKG PVPKAPVPQQ APSPQAAPQP QQVAQPLPAQ PPALAQPQYQ SPQQPPQTRW VAPRNRNAAF GQSGGAGSDS NSPGNVQPNS APSVESHPVL EKLKAAHSYN PKEFEWNLKS GRVFIIKSYS EDDIHRSIKY SIWCSTEHGN KRLDSAFRCM SSKGPVYLLF SVNGSGHFCG VAEMKSPVDY GTSAGVWSQD KWKGKFDVQW IFVKDVPNNQ LRHIRLENND NKPVTNSRDT QEVPLEKAKQ VLKIISSYKH TTSIFDDFAH YEKRQEEEEV VRKERQSRNK Q (210-559 aa encoded by BC050284)

靶标信息

Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory. Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts, thereby promoting their translation. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

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YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

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YTHDF1 promotes intrahepatic cholangiocarcinoma progression via regulating EGFR mRNA translation.

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m⁶A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.

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m⁶A-modified lincRNA Dubr is required for neuronal development by stabilizing YTHDF1/3 and facilitating mRNA translation.

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Huang J,Jiang B,Li GW,Zheng D,Li M,Xie X,Pan Y,Wei M,Liu X,Jiang X,Zhang X,Yang L,Bao L,Wang B

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Novel insight of N⁶-methyladenosine modified subtypes in abdominal aortic aneurysm.

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Novel insight of N⁶-methyladenosine modified subtypes in abdominal aortic aneurysm.

Frontiers in genetics

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Prognostic and predictive value of YTHDF1 and YTHDF2 and their correlation with tumor-infiltrating immune cells in non-small cell carcinoma.

Frontiers in oncology

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TBK1-METTL3 axis facilitates antiviral immunity.

Cell reports

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m⁶A modification confers thermal vulnerability to HPV E7 oncotranscripts via reverse regulation of its reader protein IGF2BP1 upon heat stress.

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Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 EDT 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 EDT 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 EDT 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 EDT 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 EDT 2022

Sevoflurane impairs m6A-mediated mRNA translation and leads to fine motor and cognitive deficits.

Cell biology and toxicology

Zhang L,Cheng Y,Xue Z,Li J,Wu N,Yan J,Wang J,Wang C,Chen W,Zhou T,Qiu Z,Jiang H

Fri Apr 01 00:00:00 EDT 2022

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Frontiers in immunology

Li Z,Teng M,Jiang Y,Zhang L,Luo X,Liao Y,Yang B

Fri Apr 22 00:00:00 EDT 2022

YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner.

Frontiers in immunology

Li Z,Teng M,Jiang Y,Zhang L,Luo X,Liao Y,Yang B

Fri Apr 22 00:00:00 EDT 2022

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

eLife

Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ

Fri Feb 18 00:00:00 EST 2022

The m⁶A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

eLife

Niu F,Han P,Zhang J,She Y,Yang L,Yu J,Zhuang M,Tang K,Shi Y,Yang B,Liu C,Peng B,Ji SJ

Fri Feb 18 00:00:00 EST 2022

METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway.

Cellular signalling

Cai Y,Yu R,Kong Y,Feng Z,Xu Q

Sun May 01 00:00:00 EDT 2022

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.

Journal of neuroinflammation

Ouyang H,Zhang J,Chi D,Zhang K,Huang Y,Huang J,Huang W,Bai X

Thu Dec 22 00:00:00 EST 2022

The YTHDF1-TRAF6 pathway regulates the neuroinflammatory response and contributes to morphine tolerance and hyperalgesia in the periaqueductal gray.

Journal of neuroinflammation

Ouyang H,Zhang J,Chi D,Zhang K,Huang Y,Huang J,Huang W,Bai X

Thu Dec 22 00:00:00 EST 2022

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Cell death & disease

Yao X,Li W,Li L,Li M,Zhao Y,Fang D,Zeng X,Luo Z

Wed Mar 23 00:00:00 EDT 2022

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Cell death & disease

Yao X,Li W,Li L,Li M,Zhao Y,Fang D,Zeng X,Luo Z

Wed Mar 23 00:00:00 EDT 2022

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis.

Cell death & disease

Yao X,Li W,Li L,Li M,Zhao Y,Fang D,Zeng X,Luo Z

Wed Mar 23 00:00:00 EDT 2022

GMEB2 Promotes the Growth of Colorectal Cancer by Activating ADRM1 Transcription and NF-κB Signalling and Is Positively Regulated by the m⁶A Reader YTHDF1.

Cancers

Ning Z,Wu Z,Zhang F,Yang M,Lu Z,Yu B,Long F,Guo Y,Yang K,Hu G,Zhang Y,Li X,Li L,Lin C

Thu Dec 08 00:00:00 EST 2022

UPF1 promotes rapid degradation of m⁶A-containing RNAs.

Cell reports

Boo SH,Ha H,Lee Y,Shin MK,Lee S,Kim YK

Tue May 24 00:00:00 EDT 2022

Involvement of YTHDF1 in renal fibrosis progression via up-regulating YAP.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Xing J,He YC,Wang KY,Wan PZ,Zhai XY

Tue Feb 01 00:00:00 EST 2022

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m⁶A modification.

Cancer cell international

Xu Y,Lv D,Yan C,Su H,Zhang X,Shi Y,Ying K

Fri Jan 07 00:00:00 EST 2022

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m⁶A modification.

Cancer cell international

Xu Y,Lv D,Yan C,Su H,Zhang X,Shi Y,Ying K

Fri Jan 07 00:00:00 EST 2022

METTL3 promotes lung adenocarcinoma tumor growth and inhibits ferroptosis by stabilizing SLC7A11 m⁶A modification.

Cancer cell international

Xu Y,Lv D,Yan C,Su H,Zhang X,Shi Y,Ying K

Fri Jan 07 00:00:00 EST 2022

FTO mediated ERBB2 demethylation promotes tumor progression in esophageal squamous cell carcinoma cells.

Clinical & experimental metastasis

Zhao F,Ge F,Xie M,Li Z,Zang C,Kong L,Pu Y,Zheng X,Tan Y

Mon Aug 01 00:00:00 EDT 2022

Small-Molecule Ebselen Binds to YTHDF Proteins Interfering with the Recognition of N ⁶-Methyladenosine-Modified RNAs.

ACS pharmacology & translational science

Micaelli M,Dalle Vedove A,Cerofolini L,Vigna J,Sighel D,Zaccara S,Bonomo I,Poulentzas G,Rosatti EF,Cazzanelli G,Alunno L,Belli R,Peroni D,Dassi E,Murakami S,Jaffrey SR,Fragai M,Mancini I,Lolli G,Quattrone A,Provenzani A

Fri Oct 14 00:00:00 EDT 2022

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Chen W,Wang Z,Wang S,Zan J,Zheng L,Zhao W

Thu Dec 01 00:00:00 EST 2022

Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.

Clinical immunology (Orlando, Fla.)

Sun Z,Chen W,Wang Z,Wang S,Zan J,Zheng L,Zhao W

Thu Dec 01 00:00:00 EST 2022

The expression of m6A enzymes in the hippocampus of diabetic cognitive impairment mice and the possible improvement of YTHDF1.

Brain research

Li M,Zhong X,Zhao Z,Zeng Z,Yuan Q,Xiao X,Zu X,Liu J

Tue Feb 15 00:00:00 EST 2022

Methyltransferase-like 14 suppresses growth and metastasis of renal cell carcinoma by decreasing long noncoding RNA NEAT1.

Cancer science

Liu T,Wang H,Fu Z,Wang Z,Wang J,Gan X,Wang A,Wang L

Tue Feb 01 00:00:00 EST 2022

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N⁶-Methyladenosine-Modified Yap Expression.

Research (Washington, D.C.)

Wang L,Yu P,Wang J,Xu G,Wang T,Feng J,Bei Y,Xu J,Wang H,Das S,Xiao J

Sat Jul 16 00:00:00 EDT 2022

Downregulation of circ-ZNF609 Promotes Heart Repair by Modulating RNA N⁶-Methyladenosine-Modified Yap Expression.

Research (Washington, D.C.)

Wang L,Yu P,Wang J,Xu G,Wang T,Feng J,Bei Y,Xu J,Wang H,Das S,Xiao J

Sat Jul 16 00:00:00 EDT 2022

YTHDF1 promotes breast cancer progression by facilitating FOXM1 translation in an m6A-dependent manner.

Cell & bioscience

Chen H,Yu Y,Yang M,Huang H,Ma S,Hu J,Xi Z,Guo H,Yao G,Yang L,Huang X,Zhang F,Tan G,Wu H,Zheng W,Li L

Wed Feb 23 00:00:00 EST 2022

m⁶A regulation of cortical and retinal neurogenesis is mediated by the redundant m⁶A readers YTHDFs.

iScience

Niu F,Che P,Yang Z,Zhang J,Yang L,Zhuang M,Ou X,Ji SJ

Fri Sep 16 00:00:00 EDT 2022

m⁶A regulation of cortical and retinal neurogenesis is mediated by the redundant m⁶A readers YTHDFs.

iScience

Niu F,Che P,Yang Z,Zhang J,Yang L,Zhuang M,Ou X,Ji SJ

Fri Sep 16 00:00:00 EDT 2022

YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis.

Archives of biochemistry and biophysics

He M,Li D,Fang C,Xu Q

Thu Dec 15 00:00:00 EST 2022

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Peng Z,Gong Y,Wang X,He W,Wu L,Zhang L,Xiong L,Huang Y,Su L,Shi P,Cao X,Liu R,Li Y,Xiao H

Wed Feb 02 00:00:00 EST 2022

METTL3-m⁶A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease.

Molecular therapy : the journal of the American Society of Gene Therapy

Peng Z,Gong Y,Wang X,He W,Wu L,Zhang L,Xiong L,Huang Y,Su L,Shi P,Cao X,Liu R,Li Y,Xiao H

Wed Feb 02 00:00:00 EST 2022

METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma.

EBioMedicine

Li HB,Huang G,Tu J,Lv DM,Jin QL,Chen JK,Zou YT,Lee DF,Shen JN,Xie XB

Mon Aug 01 00:00:00 EDT 2022

m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-β-induced epithelial-mesenchymal transition of lung cancer cells.

The Journal of biological chemistry

Suphakhong K,Terashima M,Wanna-Udom S,Takatsuka R,Ishimura A,Takino T,Suzuki T

Tue Nov 01 00:00:00 EDT 2022

N6-methyladenosine of Socs1 modulates macrophage inflammatory response in different stiffness environments.

International journal of biological sciences

Hu Z,Li Y,Yuan W,Jin L,Leung WK,Zhang C,Yang Y

Fri Oct 21 00:00:00 EDT 2022

Lactylation-driven METTL3-mediated RNA m⁶A modification promotes immunosuppression of tumor-infiltrating myeloid cells.

Molecular cell

Xiong J,He J,Zhu J,Pan J,Liao W,Ye H,Wang H,Song Y,Du Y,Cui B,Xue M,Zheng W,Kong X,Jiang K,Ding K,Lai L,Wang Q

Thu May 05 00:00:00 EDT 2022

METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.

Cell death & disease

Zhu Y,Peng X,Zhou Q,Tan L,Zhang C,Lin S,Long M

Mon Apr 18 00:00:00 EDT 2022

ZNF677 suppresses renal cell carcinoma progression through N6-methyladenosine and transcriptional repression of CDKN3.

Clinical and translational medicine

Li A,Cao C,Gan Y,Wang X,Wu T,Zhang Q,Liu Y,Yao L,Zhang Q

Wed Jun 01 00:00:00 EDT 2022

The pathological tissue expression pattern and clinical significance of m6A-regulatory genes in non-small cell lung cancer.

The journal of gene medicine

Li Y,Zhang X,Cai J,Ren L,Liu B,Wu M,Lu W,Li R,Zhang C,Huang C,Tong J,Liu A,Zheng Y,Ren D,Guo Y,Huang Y

Tue Feb 01 00:00:00 EST 2022

m6A demethylase FTO promotes tumor progression via regulation of lipid metabolism in esophageal cancer.

Cell & bioscience

Duan X,Yang L,Wang L,Liu Q,Zhang K,Liu S,Liu C,Gao Q,Li L,Qin G,Zhang Y

Sat May 14 00:00:00 EDT 2022

Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling.

Journal of clinical laboratory analysis

Li Z,Xu Q,Huangfu N,Chen X,Zhu J

Sat Jan 01 00:00:00 EST 2022

The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.

Evidence-based complementary and alternative medicine : eCAM

Huang Q,Li CY,Zhang N,Zhang Q,Li HY,Shen Y,Xie LS,Yu SG,Wu QF

Fri Apr 01 00:00:00 EDT 2022

The Effects of Moxibustion on Learning and Memory and m6A RNA Methylation in APP/PS1 Mice.

Evidence-based complementary and alternative medicine : eCAM

Huang Q,Li CY,Zhang N,Zhang Q,Li HY,Shen Y,Xie LS,Yu SG,Wu QF

Fri Apr 01 00:00:00 EDT 2022

YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity.

Retrovirology

N'Da Konan S,Ségéral E,Bejjani F,Bendoumou M,Ait Said M,Gallois-Montbrun S,Emiliani S

Mon Jan 31 00:00:00 EST 2022

RNA m⁶A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.

Molecular therapy : the journal of the American Society of Gene Therapy

Li J,Xie G,Tian Y,Li W,Wu Y,Chen F,Lin Y,Lin X,Wing-Ngor Au S,Cao J,He W,Wang H

Wed Apr 06 00:00:00 EDT 2022

Fusobacterium nucleatum reduces METTL3-mediated m⁶A modification and contributes to colorectal cancer metastasis.

Nature communications

Chen S,Zhang L,Li M,Zhang Y,Sun M,Wang L,Lin J,Cui Y,Chen Q,Jin C,Li X,Wang B,Chen H,Zhou T,Wang L,Hsu CH,Zhuo W

Thu Mar 10 00:00:00 EST 2022

The m⁶A methyltransferase METTL3 regulates muscle maintenance and growth in mice.

Nature communications

Petrosino JM,Hinger SA,Golubeva VA,Barajas JM,Dorn LE,Iyer CC,Sun HL,Arnold WD,He C,Accornero F

Mon Jan 10 00:00:00 EST 2022

Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H₂O₂-Induced Premature Senescence of Human Embryonic Lung Fibroblasts.

International journal of molecular sciences

Wu F,Zhang L,Lai C,Peng X,Yu S,Zhou C,Zhang B,Zhang W

Wed Aug 17 00:00:00 EDT 2022

Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.

Nutrients

Xu Z,Qin Y,Lv B,Tian Z,Zhang B

Fri Jan 07 00:00:00 EST 2022

The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity.

The Journal of experimental medicine

Ma S,Yan J,Barr T,Zhang J,Chen Z,Wang LS,Sun JC,Chen J,Caligiuri MA,Yu J

Mon Aug 02 00:00:00 EDT 2021

Comparison of RNA m⁶A and DNA methylation profiles between mouse female germline stem cells and STO cells.

Molecular therapy. Nucleic acids

Zhao X,Tian GG,Fang Q,Pei X,Wang Z,Wu J

Fri Mar 05 00:00:00 EST 2021

N(6)-methyladenosine-binding protein YTHDF1 suppresses EBV replication and promotes EBV RNA decay.

EMBO reports

Xia TL,Li X,Wang X,Zhu YJ,Zhang H,Cheng W,Chen ML,Ye Y,Li Y,Zhang A,Dai DL,Zhu QY,Yuan L,Zheng J,Huang H,Chen SQ,Xiao ZW,Wang HB,Roy G,Zhong Q,Lin D,Zeng YX,Wang J,Zhao B,Gewurz BE,Chen J,Zuo Z,Zeng MS

Wed Apr 07 00:00:00 EDT 2021

METTL14 facilitates global genome repair and suppresses skin tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America

Yang Z,Yang S,Cui YH,Wei J,Shah P,Park G,Cui X,He C,He YY

Tue Aug 31 00:00:00 EDT 2021

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N⁶-methyladenosine-dependent YTHDF binding.

Nature communications

Wang W,Shao F,Yang X,Wang J,Zhu R,Yang Y,Zhao G,Guo D,Sun Y,Wang J,Xue Q,Gao S,Gao Y,He J,Lu Z

Mon Jun 21 00:00:00 EDT 2021

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N⁶-methyladenosine-dependent YTHDF binding.

Nature communications

Wang W,Shao F,Yang X,Wang J,Zhu R,Yang Y,Zhao G,Guo D,Sun Y,Wang J,Xue Q,Gao S,Gao Y,He J,Lu Z

Mon Jun 21 00:00:00 EDT 2021

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation.

Signal transduction and targeted therapy

Li Q,Ni Y,Zhang L,Jiang R,Xu J,Yang H,Hu Y,Qiu J,Pu L,Tang J,Wang X

Tue Feb 23 00:00:00 EST 2021

Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis Through N6-Methyladenosine mRNA Methylation-Dependent Mechanism.

Hepatology (Baltimore, Md.)

Su T,Huang M,Liao J,Lin S,Yu P,Yang J,Cai Y,Zhu S,Xu L,Peng Z,Peng S,Chen S,Kuang M

Wed Sep 01 00:00:00 EDT 2021

Insufficient Radiofrequency Ablation Promotes Hepatocellular Carcinoma Metastasis Through N6-Methyladenosine mRNA Methylation-Dependent Mechanism.

Hepatology (Baltimore, Md.)

Su T,Huang M,Liao J,Lin S,Yu P,Yang J,Cai Y,Zhu S,Xu L,Peng Z,Peng S,Chen S,Kuang M

Wed Sep 01 00:00:00 EDT 2021

The m⁶ A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu J,She Y,Yang L,Zhuang M,Han P,Liu J,Lin X,Wang N,Chen M,Jiang C,Zhang Y,Yuan Y,Ji SJ

Mon Nov 01 00:00:00 EDT 2021

The m⁶ A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Yu J,She Y,Yang L,Zhuang M,Han P,Liu J,Lin X,Wang N,Chen M,Jiang C,Zhang Y,Yuan Y,Ji SJ

Mon Nov 01 00:00:00 EDT 2021

Vitamin B₁₂ Deficiency Dysregulates m6A mRNA Methylation of Genes Involved in Neurological Functions.

Molecular nutrition & food research

Mosca P,Robert A,Alberto JM,Meyer M,Kundu U,Hergalant S,Umoret R,Coelho D,Guéant JL,Leheup B,Dreumont N

Wed Sep 01 00:00:00 EDT 2021

TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.

Cell death & disease

Wang H,Wei W,Zhang ZY,Liu Y,Shi B,Zhong W,Zhang HS,Fang X,Sun CL,Wang JB,Liu LX

Fri Dec 17 00:00:00 EST 2021

TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.

Cell death & disease

Wang H,Wei W,Zhang ZY,Liu Y,Shi B,Zhong W,Zhang HS,Fang X,Sun CL,Wang JB,Liu LX

Fri Dec 17 00:00:00 EST 2021

YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.

Biochemical and biophysical research communications

Jiang D,Hou J,Qian Y,Gao Y,Gao X,Wei S

Fri Jun 11 00:00:00 EDT 2021

YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.

Biochemical and biophysical research communications

Jiang D,Hou J,Qian Y,Gao Y,Gao X,Wei S

Fri Jun 11 00:00:00 EDT 2021

Stabilization of UCA1 by N6-methyladenosine RNA methylation modification promotes colorectal cancer progression.

Cancer cell international

He RZ,Jiang J,Hu X,Lei M,Li J,Luo W,Duan L,Hu Z,Mo YY,Luo DX,Peng WX

Mon Nov 22 00:00:00 EST 2021

N6-methyladenosine regulates ATM expression and downstream signaling.

Journal of Cancer

Zhang X,Liu P,Zheng X,Wang J,Peng Q,Li Z,Wei L,Liu C,Wu Y,Wen Y,Yan Q,Ma J

Fri Nov 05 00:00:00 EDT 2021

Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine.

Cell reports

McFadden MJ,McIntyre ABR,Mourelatos H,Abell NS,Gokhale NS,Ipas H,Xhemalçe B,Mason CE,Horner SM

Tue Mar 02 00:00:00 EST 2021

Endothelial METTL3 (Methyltransferase-Like 3) Inhibits Fibrinolysis by Promoting PAI-1 (Plasminogen Activator Inhibitor-1) Expression Through Enhancing Jun Proto-Oncogene N6-Methyladenosine Modification.

Arteriosclerosis, thrombosis, and vascular biology

Bai Q,Lu Y,Chen Y,Zhang H,Zhang W,Wu H,Wen A

Wed Dec 01 00:00:00 EST 2021

m⁶A RNA methylation regulates the fate of endogenous retroviruses.

Nature

Chelmicki T,Roger E,Teissandier A,Dura M,Bonneville L,Rucli S,Dossin F,Fouassier C,Lameiras S,Bourc'his D

Mon Mar 01 00:00:00 EST 2021

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.

Nucleic acids research

Xia Z,Tang M,Ma J,Zhang H,Gimple RC,Prager BC,Tang H,Sun C,Liu F,Lin P,Mei Y,Du R,Rich JN,Xie Q

Wed Jul 21 00:00:00 EDT 2021

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase.

Nucleic acids research

Xia Z,Tang M,Ma J,Zhang H,Gimple RC,Prager BC,Tang H,Sun C,Liu F,Lin P,Mei Y,Du R,Rich JN,Xie Q

Wed Jul 21 00:00:00 EDT 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 EST 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 EST 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 EST 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 EDT 2021

METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

Molecular neurodegeneration

Zhao F,Xu Y,Gao S,Qin L,Austria Q,Siedlak SL,Pajdzik K,Dai Q,He C,Wang W,O'Donnell JM,Tang B,Zhu X

Thu Sep 30 00:00:00 EDT 2021

Integrated analysis of m⁶A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.

Aging

Zeng Y,Huang T,Zuo W,Wang D,Xie Y,Wang X,Xiao Z,Chen Z,Liu Q,Liu N,Xiao Y

Mon Jul 26 00:00:00 EDT 2021

Integrated analysis of m⁶A mRNA methylation in rats with monocrotaline-induced pulmonary arterial hypertension.

Aging

Zeng Y,Huang T,Zuo W,Wang D,Xie Y,Wang X,Xiao Z,Chen Z,Liu Q,Liu N,Xiao Y

Mon Jul 26 00:00:00 EDT 2021

YTHDF1 Promotes Cyclin B1 Translation through m⁶A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.

Cells

Lou X,Ning J,Liu W,Li K,Qian B,Xu D,Wu Y,Zhang D,Cui W

Fri Jul 02 00:00:00 EDT 2021

YTHDF1 Promotes Cyclin B1 Translation through m⁶A Modulation and Contributes to the Poor Prognosis of Lung Adenocarcinoma with KRAS/TP53 Co-Mutation.

Cells

Lou X,Ning J,Liu W,Li K,Qian B,Xu D,Wu Y,Zhang D,Cui W

Fri Jul 02 00:00:00 EDT 2021

MYC promotes cancer progression by modulating m⁶ A modifications to suppress target gene translation.

EMBO reports

Wu G,Suo C,Yang Y,Shen S,Sun L,Li ST,Zhou Y,Yang D,Wang Y,Cai Y,Wang N,Zhang H,Yang YG,Cao J,Gao P

Wed Mar 03 00:00:00 EST 2021

Differential roles of YTHDF1 and YTHDF3 in embryonic stem cell-derived cardiomyocyte differentiation.

RNA biology

Wang S,Zhang J,Wu X,Lin X,Liu XM,Zhou J

Wed Sep 01 00:00:00 EDT 2021

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

Oncoimmunology

Tsuchiya K,Yoshimura K,Inoue Y,Iwashita Y,Yamada H,Kawase A,Watanabe T,Tanahashi M,Ogawa H,Funai K,Shinmura K,Suda T,Sugimura H

Fri Oct 15 00:00:00 EDT 2021

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer.

Oncoimmunology

Tsuchiya K,Yoshimura K,Inoue Y,Iwashita Y,Yamada H,Kawase A,Watanabe T,Tanahashi M,Ogawa H,Funai K,Shinmura K,Suda T,Sugimura H

Fri Oct 15 00:00:00 EDT 2021

N6-methyladenosine promotes induction of ADAR1-mediated A-to-I RNA editing to suppress aberrant antiviral innate immune responses.

PLoS biology

Terajima H,Lu M,Zhang L,Cui Q,Shi Y,Li J,He C

Thu Jul 01 00:00:00 EDT 2021

Enterovirus 2A^pro Cleavage of the YTHDF m⁶A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.

mBio

Kastan JP,Tremblay MW,Brown MC,Trimarco JD,Dobrikova EY,Dobrikov MI,Gromeier M

Tue Apr 13 00:00:00 EDT 2021

Relaxed initiation pausing of ribosomes drives oncogenic translation.

Science advances

Dong L,Mao Y,Zhou A,Liu XM,Zhou J,Wan J,Qian SB

Mon Feb 01 00:00:00 EST 2021

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.

Nature communications

Yin H,Zhang X,Yang P,Zhang X,Peng Y,Li D,Yu Y,Wu Y,Wang Y,Zhang J,Ding X,Wang X,Yang A,Zhang R

Tue Mar 02 00:00:00 EST 2021

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.

Nature communications

Yin H,Zhang X,Yang P,Zhang X,Peng Y,Li D,Yu Y,Wu Y,Wang Y,Zhang J,Ding X,Wang X,Yang A,Zhang R

Tue Mar 02 00:00:00 EST 2021

GR-mediated transcriptional regulation of m⁶A metabolic genes contributes to diet-induced fatty liver in hens.

Journal of animal science and biotechnology

Feng Y,Li Y,Jiang W,Hu Y,Jia Y,Zhao R

Tue Dec 07 00:00:00 EST 2021

WNT/β-catenin-suppressed FTO expression increases m⁶A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.

Cell death & disease

Yang X,Shao F,Guo D,Wang W,Wang J,Zhu R,Gao Y,He J,Lu Z

Sat May 08 00:00:00 EDT 2021

WNT/β-catenin-suppressed FTO expression increases m⁶A of c-Myc mRNA to promote tumor cell glycolysis and tumorigenesis.

Cell death & disease

Yang X,Shao F,Guo D,Wang W,Wang J,Zhu R,Gao Y,He J,Lu Z

Sat May 08 00:00:00 EDT 2021

METTL3-dependent N⁶-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium.

Proceedings of the National Academy of Sciences of the United States of America

Chien CS,Li JY,Chien Y,Wang ML,Yarmishyn AA,Tsai PH,Juan CC,Nguyen P,Cheng HM,Huo TI,Chiou SH,Chien S

Tue Feb 16 00:00:00 EST 2021

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Cancer research

Pi J,Wang W,Ji M,Wang X,Wei X,Jin J,Liu T,Qiang J,Qi Z,Li F,Liu Y,Ma Y,Si Y,Huo Y,Gao Y,Chen Y,Dong L,Su R,Chen J,Rao S,Yi P,Yu S,Wang F,Yu J

Sat May 15 00:00:00 EDT 2021

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Cancer research

Pi J,Wang W,Ji M,Wang X,Wei X,Jin J,Liu T,Qiang J,Qi Z,Li F,Liu Y,Ma Y,Si Y,Huo Y,Gao Y,Chen Y,Dong L,Su R,Chen J,Rao S,Yi P,Yu S,Wang F,Yu J

Sat May 15 00:00:00 EDT 2021

YTHDF1 Promotes Gastric Carcinogenesis by Controlling Translation of FZD7.

Cancer research

Pi J,Wang W,Ji M,Wang X,Wei X,Jin J,Liu T,Qiang J,Qi Z,Li F,Liu Y,Ma Y,Si Y,Huo Y,Gao Y,Chen Y,Dong L,Su R,Chen J,Rao S,Yi P,Yu S,Wang F,Yu J

Sat May 15 00:00:00 EDT 2021

Curcumin prevents obesity by targeting TRAF4-induced ubiquitylation in m⁶ A-dependent manner.

EMBO reports

Chen Y,Wu R,Chen W,Liu Y,Liao X,Zeng B,Guo G,Lou F,Xiang Y,Wang Y,Wang X

Wed May 05 00:00:00 EDT 2021

METTL3 regulates hippocampal gene transcription via N6-methyladenosine methylation in sevoflurane-induced postoperative cognitive dysfunction mouse.

Aging

He B,Wang J

Tue Oct 05 00:00:00 EDT 2021

Reprogramming of m⁶A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.

RNA biology

Wang YJ,Yang B,Lai Q,Shi JF,Peng JY,Zhang Y,Hu KS,Li YQ,Peng JW,Yang ZZ,Li YT,Pan Y,Koeffler HP,Liao JY,Yin D

Fri Jan 01 00:00:00 EST 2021

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.

Experimental hematology & oncology

Luo X,Cao M,Gao F,He X

Fri Jun 04 00:00:00 EDT 2021

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.

Experimental hematology & oncology

Luo X,Cao M,Gao F,He X

Fri Jun 04 00:00:00 EDT 2021

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.

Experimental hematology & oncology

Luo X,Cao M,Gao F,He X

Fri Jun 04 00:00:00 EDT 2021

The m⁶A "reader" YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839.

Cell death & disease