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Invitrogen
ZBP1 Recombinant Rabbit Monoclonal Antibody (5H15L56)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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ZBP1 Antibody (703166) in ICC/IF
For immunofluorescence analysis, A549 cells were fixed and permeabilized for detection of endogenous ZBP1 using Anti-ZBP1 Recombinant Rabbit Monoclonal Antibody (Product # 703166, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 conjugate (Product # A32731, 1:2000). Nuclei (blue) were stained using ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962) and cytoskeletal F-actin (red) staining using Rhodamine Phalloidin (Product # R415, 1:300) Panel a-d) shows... View More
产品信息
703166
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5H15L56
抗原
Protein corresponding to human ZBP1 [aa6-aa166]
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2866458
产品详细信息
This antibody is predicted to react with Mouse, Rat, Bovine.
靶标信息
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DAI; DNA-dependent activator of IFN-regulatory factors; DNA-dependent activator of IRFs; RP4-718J7.1; Tumor stroma and activated macrophage protein DLM-1; Z-DNA-binding protein 1
基因别名: C20orf183; DAI; DLM-1; DLM1; ZBP1
UniProt ID: (Human) Q9H171
Entrez Gene ID: (Human) 81030
