Invitrogen

ZC3H13 Polyclonal Antibody

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ZC3H13 Antibody (PA5-36515) in WB

Western blot analysis of ZC3H13 using ZC3H13 polyclonal antibody (Product # PA5-36515) at a dilution of 1:500. Lane 1: Hela cell lysate, Lane 2: NIH-3T3 cell lysate, Lane 3: PC12 cell lysate.

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产品信息

PA5-36515

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:1,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to amino acids 1585-1632 of human ZC3H13

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 50% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2553564

产品详细信息

This antibody detects endogenous protein at a molecular weight of 200 kDa.

Purity is >95% by SDS-PAGE.

靶标信息

The zinc finger CCCH domain-containing protein 13 (ZC3H13) is a 1668 amino acid protein that contains one C3H1-type zinc finger. ZC3H13 is phosphorylated upon DNA damage, most likely by ATM or ATR. Two isoforms of ZC3H13 exists as a result of alternative splicing events. The gene encoding ZC3H13 maps to chromosome 13, which contains around 114 million base pairs and 400 genes. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.

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