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ZFP36 Antibody (PA5-117330) in ICC/IF
Immunocytochemistry analysis of ZFP36 in paraffin-embedded human THP-1, Red: alpha tubulin. Samples was treated with Citrate buffer (pH 6, 15 min) for antigen retrieval and incubated in ZFP36 polyclonal antibody (Product # PA5-117330) using a dilution of 1:1000, followed by DAPI.
产品信息
PA5-117330
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human Tristetraprolin. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
2.47 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2901960
产品详细信息
Centrifuge briefly prior to opening.
靶标信息
ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: G0/G1 switch regulatory protein 24; Growth factor-inducible nuclear protein NUP475; mRNA decay activator protein ZFP36; TPA-induced sequence 11; Tristetraprolin; tristetraproline; Zfp-36; Zinc finger protein 36; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog; zinc finger protein, C3H type, 36 homolog
基因别名: G0S24; GOS24; NUP475; RNF162A; TIS11; TIS11A; TIS11D; TISII; TTP; Zfp-36; ZFP36
UniProt ID: (Human) P26651, (Mouse) P22893
Entrez Gene ID: (Human) 7538, (Mouse) 22695
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
mRNA catabolic process
response to wounding
regulation of keratinocyte proliferation
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
regulation of tumor necrosis factor production
miRNA mediated inhibition of translation
p38MAPK cascade
response to starvation
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
positive regulation of fat cell differentiation
regulation of keratinocyte differentiation
negative regulation of erythrocyte differentiation
mRNA transport
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
3'-UTR-mediated mRNA destabilization
3'-UTR-mediated mRNA stabilization
cellular response to lipopolysaccharide
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
cellular response to glucocorticoid stimulus
cellular response to granulocyte macrophage colony-stimulating factor stimulus
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of keratinocyte apoptotic process
positive regulation of intracellular mRNA localization
regulation of transcription from RNA polymerase II promoter
intracellular signal transduction
negative regulation of myeloid cell differentiation
negative regulation of inflammatory response
RNA destabilization
