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ZIPK Antibody (PA1-12521) in WB
Western blot was performed using Anti-ZIPK Polyclonal Antibody (Product # PA1-12521) and a 52 kDa band corresponding to DAPK3 was observed across cell lines tested except LNCaP which is reported to be low. A doublet banding pattern is observed, which is probably due to autophosphorylation of the DAPK3 which is reported in literatures. Modified whole cell extracts (1% SDS) (30 µg lysate) of DU 145 (Lane 1), PC-3 (Lane 2), HeLa (Lane 3), LNCaP (Lane 4), U-87 MG (Lane 5) and Jurkat (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Pr... View More
产品信息
PA1-12521
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 279-298 of human ZIP kinase.
偶联物
Unconjugated
形式
Liquid
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_1088350
产品详细信息
A suggested positive control for this product is Jurkat or HeLa whole cell lysate.
靶标信息
DAPK3 is a serine/threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. DAPK3 is encoded by ZIPK and is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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