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ZRANB1 Antibody (CF810024) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ZRANB1 (RC220808, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ZRANB. Positive lysates LY413719 (100 µg) and LC413719 (20 µg) can be purchased separately from OriGene.
产品信息
CF810024
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI2A10
抗原
Human recombinant protein fragment corresponding to amino acids 208-296 of human ZRANB1 produced in E.coli.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
ZRANB1 is a positive regulator of the Wnt signaling pathway that specifically cleaves 'Lys-63'-linked ubiquitin chains. It acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription and may also modulate TNF-alpha signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp762P2216; hTrabid; TRAF-binding domain-containing protein; TRAF-binding protein; TRAF-binding protein domain; Ubiquitin thioesterase ZRANB1; Zinc finger Ran-binding domain-containing protein 1; zinc finger, RAN-binding domain containing 1; zinc finger, RAN-binding domain containing 1 protein-like
基因别名: 9330160G10Rik; D7Wsu87e; Gm1956; TRABID; ZRANB1
UniProt ID: (Human) Q9UGI0, (Mouse) Q7M760
Entrez Gene ID: (Rat) 100360606, (Human) 54764, (Mouse) 360216
cytoskeleton organization
cell migration
regulation of cell morphogenesis
positive regulation of Wnt signaling pathway
protein K29-linked deubiquitination
protein K63-linked deubiquitination
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
protein K33-linked deubiquitination
Wnt signaling pathway
proteolysis
