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alpha-Defensin 3 Antibody (PA5-103123) in ICC/IF
Immunocytochemistry analysis of alpha-Defensin 3 in HepG2 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with alpha-Defensin 3 polyclonal antibody (Product # PA5-103123) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 co... View More
产品信息
PA5-103123
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human DEFA3(Accession P59666), corresponding to amino acid residues I36-Q86.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2852493
产品详细信息
Antibody detects endogenous levels of total Defensin alpha3.
靶标信息
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-defensin 3; defensin 3, neutrophil-specific; Defensin, alpha 3; defensin, alpha 3, neutrophil-specific; defensin, alpha, 27; Defensin-related cryptdin-3; HNP-3; HP-3; Neutrophil defensin 3; neutrophil peptide 3
基因别名: DEF3; Defa27; DEFA3; Defcr-3; Defcr3; HNP-3; HNP3; HP-3; HP3
UniProt ID: (Human) P59666, (Mouse) P28310
Entrez Gene ID: (Human) 1668, (Mouse) 13237
innate immune response in mucosa
antibacterial humoral response
intracellular estrogen receptor signaling pathway
killing of cells of other organism
innate immune response
defense response to Gram-positive bacterium
defense response to fungus
defense response to virus
response to drug
defense response to bacterium
defense response to Gram-negative bacterium
cellular response to lipopolysaccharide
