Invitrogen

alpha Internexin Polyclonal Antibody

alpha Internexin Antibody in Immunocytochemistry (ICC/IF)

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alpha Internexin Antibody (PA1-10017) in ICC/IF

Immunofluorescent analysis of alpha internexin in rat cerebellum section. The rat cerebellum section was obtained following transcardial perfusion of the rat with 4% paraformaldehyde, brain was post fixed for 24 hours, and cut to 45µM. Free-floating sections were stained using an alpha internexin polyclonal antibody (Product # PA1-10017) at a dilution of 1:2,000 as seen in green, using a GFAP polyclonal ant... View More

alpha Internexin Antibody in Western Blot (WB)

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产品信息

PA1-10017

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:10,000-1:20,000

免疫组化 (IHC)

1:500-1:1,000

免疫细胞化学 (ICC/IF)

1:500-1:1,000

产品规格

种属反应

Bovine, Horse, Human, Mouse, Pig, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Purified, recombinant rat alpha-internexin, expressed in E. coli.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

Conc. Not Determined

保存液

whole serum

内含物

5mM sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2127487

产品详细信息

In Western blot, a prominent band at ~66 kDa is observed, as well as smaller lower bands which are apparently degradation products. A minor band at ~150 kDa is also seen, resulting from dimerization of alpha-internexin.

靶标信息

alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 66 kDa neurofilament protein; Alpha-internexin; Alpha-Inx; FLJ18662; FLJ57501; internexin neuronal intermediate filament protein, alpha; internexin, alpha; MGC12702; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; NF-66

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基因别名: AV028420; INA; Inexa; Intlaa; NEF5; NF-66; NF66; TXBP-1

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UniProt ID: (Human) Q16352, (Bovine) Q08DH7, (Mouse) P46660