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alpha Internexin Antibody (PA1-4737) in ICC/IF
Immunocytochemistry analysis of alpha Internexin in neurons and glia cells showing specific labeling of neuronal processes with alpha Internexin polyclonal antibody (Product # PA1-4737) with a dilution of 1:500 (red), and specific labeling of microglia with Anti-Coronin 1a (green).
产品信息
PA1-4737
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Chicken
/ IgY
分类
Polyclonal
类型
Antibody
抗原
Recombinant rat alpha-internexin expressed in and purified from E. coli
偶联物
形式
Liquid
浓度
Conc. Not Determined
纯化类型
IgY fraction
保存液
PBS
内含物
10mM sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
RRID
AB_10977046
产品详细信息
In Western blot, a band at ~66 kDa is detected. Minor bands of approximately 50 kDa and 150 kDa are also detected, which most likely correspond to alpha-internexin breakdown products and covalent dimers, respectively.
靶标信息
alpha-Internexin is a Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 66 kDa neurofilament protein; Alpha-internexin; Alpha-Inx; FLJ18662; FLJ57501; internexin neuronal intermediate filament protein, alpha; internexin, alpha; MGC12702; Neuro; Neurofilament 5; neurofilament 5 (66kD); Neurofilament 66; neurofilament-66; neurofilament-66, tax-binding protein; NF-66
基因别名: AV028420; INA; Inexa; Intlaa; NEF5; NF-66; NF66; TXBP-1
UniProt ID: (Human) Q16352, (Bovine) Q08DH7, (Mouse) P46660
Entrez Gene ID: (Human) 9118, (Bovine) 532236, (Mouse) 226180, (Rat) 24503
multicellular organism development
nervous system development
cell differentiation
intermediate filament cytoskeleton organization
neurofilament cytoskeleton organization
substantia nigra development
tissue regeneration
postsynaptic actin cytoskeleton organization
postsynaptic intermediate filament cytoskeleton organization
cellular response to leukemia inhibitory factor
