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产品信息
10546-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
alpha-SNAP Fusion Protein Ag0836 (1-295 aa encoded by BC007432)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody recognizes a 33 kDa protein in SDS page.
Immunogen sequence: MDNSGKEAE AMALLAEAER KVKNSQSFFS GLFGGSSKIE EACEIYARAA NMFKMAKNWS AAGNAFCQAA QLHLQLQSKH DAATCFVDAG NAFKKADPQE AINCLMRAIE IYTDMGRFTI AAKHHISIAE IYETELVDIE KAIAHYEQSA DYYKGEESNS SANKCLLKVA GYAALLEQYQ KAIDIYEQVG TNAMDSPLLK YSAKDYFFKA ALCHFCIDML NAKLAVQKYE ELFPAFSDSR ECKLMKKLLE AHEEQNVDSY TESVKEYDSI SRLDQWLTTM LLRIKKTIQG DEEDLR (1-295 aa encoded by B C007432)
靶标信息
SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs (SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-to-endosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha snap; alpha soluble NSF attachment protein; alpha-SNAP; Alpha-soluble NSF attachment protein; hydrocephaly with hop gait; N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; SNAP-alpha
基因别名: 1500039N14Rik; a-SNAP; alpha-SNAP; AW209189; hyh; NAPA; RA81; Snap; SNAPA; SNARE
UniProt ID: (Human) P54920, (Rat) P54921, (Mouse) Q9DB05
Entrez Gene ID: (Human) 8775, (Rat) 140673, (Mouse) 108124
intracellular protein transport
ER to Golgi vesicle-mediated transport
retrograde vesicle-mediated transport, Golgi to ER
intra-Golgi vesicle-mediated transport
brain development
regulation of synaptic vesicle priming
neuron differentiation
synaptic transmission, glutamatergic
SNARE complex disassembly
apical protein localization
COPII vesicle coating
membrane fusion
transport
protein transport
vesicle-mediated transport
