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Invitrogen
beta-2 Microglobulin Recombinant Superclonal Antibody (4HCLC)
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
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beta-2 Microglobulin Antibody (710274) in WB
Western blot analysis of B2M in whole cell extracts from HeLa (lane 1), U937 (lane 2), and A431 cells (lane 3) using a B2M Recombinant Rabbit Polyclonal Antibody (Product # 710274) at a dilution of 1 µg/mL. Samples were detected using chemiluminescence (ECL). Results show a band at ~12kDa.
产品信息
710274
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
克隆号
4HCLC
抗原
Recombinant protein corresponding to amino acids 21-119 of human b2-microglobulin.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532658
产品详细信息
This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B-F; B2-microglobulin; Beta 2 microglobin; Beta 2 microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; Beta-2-microglobulin; Beta2 microglobulin; MHC Class I; microglobulin beta-2; Orla-B2m
基因别名: B2M; CDABP0092; HDCMA22P; IMD43
UniProt ID: (Human) P61769
Entrez Gene ID: (Human) 567
retina homeostasis
positive regulation of T cell mediated cytotoxicity
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
positive regulation of T cell cytokine production
regulation of membrane depolarization
negative regulation of neuron projection development
antibacterial humoral response
antigen processing and presentation of endogenous peptide antigen via MHC class I
positive regulation of protein binding
T cell differentiation in thymus
protein refolding
response to drug
cellular protein metabolic process
innate immune response
response to cadmium ion
positive regulation of receptor-mediated endocytosis
regulation of defense response to virus by virus
regulation of immune response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
iron ion homeostasis
interferon-gamma-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to iron ion
negative regulation of receptor binding
positive regulation of receptor binding
positive regulation of ferrous iron import into cell
positive regulation of ferrous iron binding
positive regulation of transferrin receptor binding
