Invitrogen

beta Dystroglycan Monoclonal Antibody (GT2812)

beta Dystroglycan Antibody in Western Blot (WB)

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beta Dystroglycan Antibody (MA5-35932) in WB

Western Blot analysis of beta Dystroglycan in wild-type (WT) and DAG1/beta Dystroglycan knockout (KO) 293T cell extract. Sample was separated with 10% SDS-PAGE, incubated with monoclonal antibody (Product # MA5-35932) at a dilution of 1:500, and followed by HRP-conjugated anti-mouse IgG.

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产品信息

MA5-35932

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

GT2812

抗原

Recombinant protein encompassing a sequence within the center region of human DAG1/beta Dystroglycan. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2866549

靶标信息

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

仅用于科研。不用于诊断过程。未经明确授权不得转售。